PAIN
Volume 33, Issue 1 , Pages 109-121, April 1988

Stimulation-produced analgesia (SPA) from brain-stem and diencephalic sites in the rat: Relationships between analgesia, aversion, seizures and catalepsy

  • Michael J. Morgan

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr. M.J. Morgan, Department of Psychology, McGill University, 1205 Dr. Penfield Avenue, Montreal, Que. H3A 1B1, Canada.
    • ,
  • Keith B.J. Franklin

Department of Psychology, McGill University, Montreal, Que. H3A 1B1 Canada

Received 1 July 1987; received in revised form 5 October 1987; accepted 9 November 1987.

Abstract 

Electrical stimulation of dorsal and dorsolateral periaqueductal gray (PAG) and internal capsule (IC) sites in the rat elicited tail flick and formalin test stimulation-produced analgesia (SPA). SPA from PAG sites was associated with aversion. SPA from IC sites was associated with aversion, generalized seizures and catalepsy. Ventrobasal nucleus of thalamus (VB) stimulation did not elicit analgesia or aversion but did induce behavior characteristic of limbic seizures. A sub-anesthetic dose of sodium pentobarbital (20 mg/kg) suppressed IC stimulation-produced generalized seizures and catalepsy, and attenuated, but did not eliminate, tail flick test analgesia. These data suggest that SPA from IC sites in the rat is partially confounded with reduced responsivity. The hypothesis that SPA associated with aversion may represent a form of stress-induced analgesia is discussed.

Keywords:  Stimulation-produced analgesia, Tail flick test, Formahn test, Aversion, Generalized seizure, Catalepsy, Periaqueductal gray, Internal capsule, Ventrobasal nucleus of thalamus

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PII: 0304-3959(88)90210-2

PAIN
Volume 33, Issue 1 , Pages 109-121, April 1988

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