PAIN
Volume 64, Issue 3 , Pages 559-568 , March 1996

Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat

Received 24 April 1995 ,Revised 1 August 1995 ,Accepted 1 August 1995.

References 

  1. Alhava E. Reported adverse drug reactions and consumption of non-steroidal anti-inflammatory drugs. Pharmacol. Toxicol. 1994;75(Suppl. 11):37–43
  2. Amano Y, Lee SW, Allison AC. Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: mediation by decreased mRNA stability. Mol. Pharmacol. 1993;43:176–182
  3. Barnes PJ, Adcock I. Anti-inflammatory actions of steroids: molecular mechanisms. TIPS. 1993;14:436–441
  4. Bekemeier H, Hirschelmann R. On steroid-saving drug combination in carrageenin paw edema and adjuvant arthritis. Arzneim-Forch/Drug Res. 1986;36:1521–1524
  5. Besson JM, Chaouch A. Peripheral and spinal mechanisms of nociception. Physiol. Rev. 1987;67:67–186
  6. Brenner T, Boneh A, Shohami E, Abramsky O, Weidenfeld J. Glucocorticoid regulation of eicosanoid production by glial cells under basal and stimulated condition. J. Neuroimmunol. 1992;40:273–279
  7. Buritova J, Honoré P, Chapman V, Besson JM. Concurrent reduction of inflammation and spinal Fos-LI neurons by systemic diclofenac in the rat. Neurosci. Lett. 1995;188:175–178
  8. Buritova J, Honoré P, Chapman V, Besson JM. Carrageenan oedema and spinal Fos-LI neurones are reduced by piroxicam in the rat. NeuroReport. 1995;6:1–4
  9. Campbell WI, Kendrick RW. Postoperative dental pain: a comparative study of anti-inflammatory and analgesic agents. Ulster Med. J. 1991;60:39–43
  10. Chandrabose KA, Lapetina EG, Schmitges CJ, Siegel MI, Cuatrecasas P. Action of corticosteroids in regulation of prostaglandin biosynthesis in cultured fibroblast. In: Proc. Natl. Acad. Sci. USA. 75:1978;p. 214–217
  11. Chapman V, Honoré P, Buritova J, Besson JM. Cholecystokinin B receptor antagonism enhances the ability of a low dose of morphine to reduce c-Fos expression in the spinal cord of the rat. Neuroscience. 1995;67:731–735
  12. Crofford LJ, Wilder RL, Ristimaki AP, Sano H, Remmers EF, Epps HR, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J. Clin. Invest. 1994;93:1095–1101
  13. Draisci G, Iadarola MJ. Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord. Mol. Brain Res. 1989;6:31–37
  14. Dray A, Urban L, Dickenson A. Pharmacology of chronic pain. TIPS. 1994;15:190–197
  15. Dray A, Bevan S. Inflammation and hyperalgesia/highlighting the team effort. TIPS. 1993;14:287–290
  16. Edwards DR. Cell signalling and the control of gene transcription. TIPS. 1994;15:239–259
  17. Ferreira SH. Prostanglandins, aspirin-like drugs and analgesia. Nature. 1972;240:200–203
  18. Fereira SH, Moncada S, Vane JR. Prostaglandin and the mechanism of analgesia produced by aspirin-like drugs. Br. J. Pharmacol. 1973;49:86–97
  19. Flower RJ, Blackwell GJ. Anti-inflammatory steroids induced biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation. Nature. 1979;278:456–459
  20. Flower RJ, Gryglewski R, Herbaczynska-Cedro K, Vane JR. Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature. 1972;238:104–106
  21. Glaser KB, Mobilio D, Chang JY, Senko N. Phospholipase A2 enzymes: regulation and inhibition. TIPS. 1993;14:92–98
  22. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 1988;32:77–88
  23. Haynes RC. Adrenocorticotropic hormone: adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In:  Goodman A,  Gilman A,  Rail TW,  Nies AS,  Taylor P editor. The Pharmacological Basis of Therapeutics. Singapore: McGraw; 1991;
  24. Herdegen T, Kovary K, Leah J, Bravo R. Specific temporal and spatial distribution of JUN, FOS and KROX-24 proteins in spinal neurons following noxious transsynaptic stimulation. J. Comp. Neurol. 1991;313:178–191
  25. Hirata F, Schiffmann E, Venkatasubramanian K, Salomon D, Axelrod J. A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. In: Proc. Natl. Acad. Sci. USA. 77:1980;p. 2533–2536
  26. Hirschelmann R, Bekemeier H. Problems and results in testing the possible mode of anti-inflammatory glucocorticoid action in carrageenin rat paw oedema: advantages of local substance injection. Int. J. Tiss. React. 1984;6:471–475
  27. Hong SL, Levine L. Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. In: Proc. Natl. Acad. Sci. USA. 73:1976;p. 1730–1734
  28. Honoré P, Buritova J, Besson JM. Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin. Eur. J. Pharmacol. 1995;272:249–259
  29. Honoré P, Chapman V, Buritova J, Besson JM. Reduction of carrageenin oedema and the associated c-Fos expression in the rat lumbar spinal cord by nitric oxide synthase inhibitor. Br. J. Pharmacol. 1995;114:77–84
  30. Honoré P, Buritova J, Besson JM. Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory sings produced by carrageenin. Pain. 1995;63:365–375
  31. Hsu S, Raine L, Fanger H. Use of avidin-biotin-peroxydase complex (ABC) in immunoperoxydase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures. J. Histochem. Cytochem. 1981;29:577–580
  32. Hunt SP, Pini A, Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature. 1987;328:632–634
  33. Iadarola MJ, Brady LS, Draisci G, Dubner R. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioural parameters and opioid receptor binding. Pain. 1988;35:313–326
  34. Insel PA. Analgesic-antipyretics and antiinflammatory agents; drugs employed in treatment of rheumatoid arthritis and gout, The pharmacological basis of therapeutics. In:  Goodman A,  Gilman A,  Rail TW,  Nies AS,  Taylor P editor. The Pharmacological Basis of Therapeutics. Singapore: McGraw-Hill; 1991;
  35. Joris J, Costello A, Dubner R, Hargreaves K. Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia. Pain. 1990;43:95–103
  36. Kayser V, Guilbaud G. Local and remote modifications of nociceptive sensitivity during carrageenan-induced inflammation in the rat. Pain. 1987;28:99–107
  37. Lauritsen K, Laursen LS, Kjeldsen J, Bukhave K, Rask-Madsen J. Inhibition of eicosanoid synthesis and potential therapeutic benefits of ‘dual pathway inhibition’. Pharmacol., Toxicol. 1994;75(Suppl. 11):9–13
  38. Lembeck F, Popper H, Juan H. Release of prostaglandins by bradykinin as an intrinsic mechanism of its algesic effets. Br. J. Pharmacol. 1976;102:297–304
  39. Levine JD, Fields HL, Basbaum AI. Peptides and the primary afferent nociceptor. J. Neurosci. 1993;13:2273–2286
  40. Levine JD, Taiwo Y. Inflammatory pain. In:  Wall PD,  Melzack R editor. Textbook of Pain. Edinburgh: Churchill Livingstone; 1994;
  41. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. In: Proc. Nail. Acad. Sci. USA. 91:1994;p. 3228–3232
  42. Meade EA, Smith WL, De Witt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 1993;268:6610–6614
  43. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. In: Proc. Natl. Acad. Sci. USA. 90:1993;p. 11693–11697
  44. Miyasaka K, Mikami T. Comparison of the anti-inflammatory effects of dexamethasone, indomethacin and BW755C on carrageenin-induced pleurisy in rats. Eur. J. Pharmacol. 1982;77:229–236
  45. Menétrey D, de Pommery J, Baimbridge KG, Thomasset M. Calbindin-D28K (CaBP28k)-like immunoreactivity in ascending projections. I. Trigemial nucleus caudalis and dorsal vagal complex projections. Eur. J. Neurosci. 1992;4:61–69
  46. Molander C, Xu Q, Grant G. The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J. Comp. Neurol. 1984;230:133–141
  47. Morgan JI, Curran T. Immediate-early genes: ten years on. Trends Neurosci. 1995;18:66–67
  48. Noguchi K, Dubner R, Ruda MA. Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins. Neuroscience. 1992;46:561–570
  49. Noguchi K, Kowalski K, Traub R, Solodkin A, Iadarola MJ, Ruda MA. Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons. Mol. Brain Res. 1991;10:227–233
  50. O'Banion MK, Winn V, Young DA. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. In: Proc. Nall. Acad. Sci. USA. 89:1992;p. 4888–4892
  51. Otterness IG, Wiseman EH, Gans DJ. A comparison of the carrageenan edema test and ultraviolet light-induced erythema test as predictors of the clinical dose in rheumatoid arthritis. Agents Actions. 1979;9:177–183
  52. Ponta H, Cato ACB, Herrlich P. Interference of pathway specific transcription factors. Biochim. Biophys. Acta. 1992;1129:255–261
  53. Presley RW, Menétrey D, Levine JD, Basbaum AI. Systemic morphine suppresses noxious stimulus-evoked Fos proteinlike immunoreactivity in the rat spinal cord. J. Neurosci. 1990;10:323–335
  54. Rao TS, Mathur M, Bhide NK. Late inflammatory swelling by carrageenan in rat's subcutaneous neck tissue. Ind. J. Physiol. Pharmacol. 1988;32:212–214
  55. Raz A, Wyche A, Needleman P. Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases. In: Proc. Nail. Acad. Sci. USA. 86:1989;p. 1657–1661
  56. Russo-Marie F, Paing M, Duval D. Involvement of glucocorticoid receptors in steroid-induced inhibition of prostaglandin secretion. J. Biol. Chem. 1979;254:8498–8504
  57. Schalkwijk C, Vervoordeldonk M, Pfeilschifter J, Märki F, Bosch H. Cytokinine- and forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E2 in rat mesanglial cells is prevented by dexamethasone. Biochem. Biophys. Res. Commun. 1991;180:46–52
  58. Schnle R, Evans M. Cross-coupling of signal transduction pathways: zing finger meets leucine zipper. Trends Genet. 1991;7:377–381
  59. Tsurufuji S, Sugio K, Fumihiko T, Yoshizawa S. Blockade by antiglucocorticoids, actinomycin D and cycloheximide of anti-inflammatory action of dexamethasone against bradykinin. J. Pharmacol. Exp. Ther. 1980;212:225–231
  60. Tsurufuji S, Sugio K, Takemasa F. The role of glucocorticoid receptor and gene expression in the anti-inflammatory action of dexamethasone. Nature. 1979;280:408–410
  61. Tölle TR, Castro-Lopes JM, Coimbra A, Zieglgansberger W. Opiates modify induction of c fos proto-oncogene in the spinal cord of the rat following noxious stimulation. Neurosci. Lett. 1990;111:46–51
  62. Tölle TR, Herdegen T, Schadrack J, Bravo R, Zimmermann M, Zieglgansberger W. Application of morphine prior to noxious stimulation differentially modulates expression of Fos, Jun and Krox-24 proteins in rat spinal cord neurons. Neuroscience. 1994;58:305–321
  63. Tölle TR, Schadrack J, Castro-Lopes JM, Evan G, Roques BP, Zieglgansberger W. Effects of Kelatorphan and morphine before and after noxious stimulation on immediate-early gene expression in rat spinal cord neurons. Pain. 1994;56:103–112
  64. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature New. Biol. 1971;231:232–235
  65. Watanabe S, Bruera E. Corticosteroids as adjuvant analgesics. J. Pain Sympt. Manag. 1994;9:442–445
  66. Weber CR, Griffin JM. Evaluation of dexamethasone for reducing postoperative edema and inflammatory response after orthognathic surgery. J. Oral Maxillofac. Surg. 1994;52:35–39
  67. Willis WD, Coggeshall RE. Sensory Mechanisms of the Spinal Cord. New York: Plenum Press; 1991;
  68. Winter CA, Risley EA, Nuss GW. Carrageenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. In: Proc. Soc. Exp. Biol. Med. 111:1962;p. 544–547
  69. Zieglgansberger W, Tölle TR. The pharmacology of pain signalling. Curr. Opin. Neurobiol. 1993;3:611–618
  70. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109–110

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PAIN
Volume 64, Issue 3 , Pages 559-568 , March 1996

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