PAIN
Volume 64, Issue 3 , Pages 579-587, March 1996

Behavioral outcome of posterior parietal cortex injury in the monkey

  • W.K. Dong

      Affiliations

    • Corresponding Author InformationCorresponding author: Dr. Willie K. Dong, Department of Anesthesiology (Box 356540), School of Medicine, University of Washington, Seattle, WA 98195-6540, USA.
    • ,
  • T. Hayashi

      Affiliations

    • Present address: Dr. Takahiko Hayashi, Department of Anesthesiology, School of Medicine, Osaka University, 2-2 Yamada-oka, Suita City, Osaka 565, Japan.
    • ,
  • V.J. Roberts

      Affiliations

    • Present address: Dr. Vicki J. Roberts, Department of Neurology, Neurobehavioral Program, School of Medicine, Wesley Woods Health Center, Emory University, 1841 Clifton Road, N.E., Atlanta, GA 30329, USA.
    • ,
  • B.M. Fusco

      Affiliations

    • Present address: Dr. Bruno M. Fusco, Department of Experimental Medicine, Headache Center, University La Sapienza, 00161 Rome, Italy.
    • ,
  • E.H. Chudler

Departments of Anesthesiology and Psychology and Multidisciplinary Pain Center, University of Washington School of Medicine, Seattle, WA 98195 USA

Received 12 January 1995; received in revised form 18 September 1995; accepted 11 October 1995.

Abstract 

Recent studies from our laboratory have characterized the response properties of trigeminal nociceptive neurons located in the posterior parietal cortex of awake monkeys, particularly in the rostral portion of the inferior parietal lobule and parietal operculum within the lateral sulcus. The stimulus intensity-response functions of some nociceptive neurons were significantly correlated to the stimulus intensity-escape frequency functions. The present study provides evidence that trauma to the posterior parietal cortex alters pain sensibility to the contralateral face. Although thermal pain tolerance was dramatically altered, the discriminative aspect of thermosensitivity may have remained intact. Our results complement the recent findings of clinical studies concerned with pain and damage to the posterior parietal cortex and of experimental studies concerned with painful stimulation and changes in regional cerebral blood flow. The role of the posterior parietal cortex in nociception and pain is discussed in relation to the first somatosensory area and to unilateral spatial neglect (inattention).

Keywords:  Parietal cortex, Brain trauma, Thermal stimulation, Pain tolerance, Thermosensitivity, (Monkey)

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PII: 0304-3959(95)00215-4

PAIN
Volume 64, Issue 3 , Pages 579-587, March 1996

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