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PAIN
Volume 114, Issue 1
, Pages 3-6
, March 2005
Mechanisms of the placebo response and their impact on clinical trials and clinical practice
References
- . Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J Neurosci. 1999;19:484–494
- . Response variability to analgesics: a role for non-specific activation of endogenous opioids. Pain. 2001;90:205–215
- Bausell RB, Lao L, Bergman S, Lee W-L, Berman BM. Is acupuncture analgesia an expectancy effect? Preliminary evidence based upon participants' perceived assignments in two placebo controlled trials. Eval Health Prof 2005; in press.
- . How the doctor's words affect the patient's brain. Eval Health Prof. 2002;25:369–386
- . Potentiation of placebo analgesia by proglumide. Lancet. 1995;346:1231
- . Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. Pain. 1997;71:135–140
- . Inducing placebo respiratory depressant responses in humans via opioid receptors. Eur J Neurosci. 1999;11:625–631
- . Somatotopic activation of opioid systems by target-directed expectations of analgesia. J Neurosci. 1999;19:3639–3648
- . Open versus hidden medical treatments: the patient's knowledge about a therapy affects the therapy outcome. Prev Treat. 2003;http://journals.apa.org/prevention/volume6/toc-jun-03.html
- . Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. J Neurosci. 2003;23:4315–4323
- . Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus. Nat Neurosci. 2004;7:587–588
- . Overt versus covert treatment for pain, anxiety, and Parkinson's disease. Lancet Neurol. 2004;3:679–684
- . Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease. Science. 2001;293:1164–1166
- . Influence of context effects on health outcomes: a systematic review. Lancet. 2001;357:757–762
- . Placebo and naloxone can alter post-surgical pain by separate mechanisms. Nature. 1983;306:264–265
- . Placebo effect in the rat. Science. 1962;138:677–678
- . The placebo effect in alternative medicine: can the performance of a healing ritual have clinical significance?. Ann Intern Med. 2002;136:817–825
- . Hidden administration as ethical alternatives to the balanced placebo design. Prev Treat. 2003;http://journals.apa.org/prevention/volume6/toc-jun-03.html
- . Influence of the method of drug administration on analgesic response. Nature. 1984;312:755–756
- . The mechanism of placebo analgesia. Lancet. 1978;2:654–657
- . The neural correlates of placebo effects: a disruption account. Neuroimage. 2004;22:447–455
- . Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial. Arch Gen Psychiatry. 2004;61:412–420
- . Placebo and opioid analgesia—imaging a shared neuronal network. Science. 2002;295:1737–1740
- . Response expectancies in placebo analgesia and their clinical relevance. Pain. 2001;93:77–84
- . Assessing placebo effects without placebo groups: an untapped possibility?. Pain. 2001;90:201–203
- . An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain. 1999;83:147–156
- . Explanatory mechanisms for placebo effects: Pavlovian conditioning. In: Guess HA, Kleinman A, Kusek JW, Engel LW editor. The science of the placebo: toward an interdisciplinary research agenda. London: BMJ Books; 2002;p. 133–157
- . The placebo effect: dissolving the expectancy versus conditioning debate. Psychol Bull. 2004;130:324–340
- . Willing oneself better on placebo-effective in its own right. Lancet. 2004;364:227–228
- . A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia. Pain. 2002;99:443–452
- . Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. J Neurosci. 2003;23:11461–11468
- . Placebo-induced changes in fMRI in the anticipation and experience of pain. Science. 2004;303:1162–1166
- . Declaration of helsinki. Amended by the 52nd WMA general assembly. J Am Med Assoc. 2000;284:3043–3045
- World Medical Association, Note of Clarification on Paragraph 29, Washington; 2002, http://www.wma.net/e/policy/b3.htm
PII: S0304-3959(04)00582-2
doi: 10.1016/j.pain.2004.12.012
© 2004 International Association for the Study of Pain. Published by Elsevier Inc. All rights reserved.
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PAIN
Volume 114, Issue 1
, Pages 3-6
, March 2005

