PAIN
Volume 118, Issue 1 , Pages 35-42 , November 2005

Prolonged rhythmic gum chewing suppresses nociceptive response via serotonergic descending inhibitory pathway in humans

  • Yuko Mohri

      Affiliations

    • Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
    • Department of Physiology, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku Tokyo 143-8540, Japan
  • ,
  • Masaki Fumoto

      Affiliations

    • Department of Physiology, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku Tokyo 143-8540, Japan
  • ,
  • Ikuko Sato-Suzuki

      Affiliations

    • Department of Physiology, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku Tokyo 143-8540, Japan
  • ,
  • Masahiro Umino

      Affiliations

    • Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
  • ,
  • Hideho Arita

      Affiliations

    • Department of Physiology, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku Tokyo 143-8540, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +813 3762 2335; fax: +81 3 3762 8148.

Received 29 December 2004 ,Revised 17 June 2005 ,Accepted 18 July 2005.

References 

  1. Aprison MH, Takahashi R, Tachiki K. Hypersensitive serotonergic receptors involved in clinical depression. In:  Haber B,  Aprison MH editor. A theory. Neuropharmacology and behavior. New York: Plenum Press; 1978;p. 23–53
  2. Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I. Imaging how attention modulates pain in humans using functional MRI. Brain. 2002;125:310–319[http://brain.oxfordjournals.org/cgi/reprint/125/2/310.]
  3. Basbaum AI, Fields HL. Endogeous pain control systems: brainstem spinal pathways and endorphin circuitry. Ann Rev Neurosci. 1984;7:309–328
  4. Fumoto M, Sato-Suzuki I, Seki Y, Mohri Y, Arita H. Appearance of high-frequency alpha band with disappearance of low-frequency alpha band in EEG is produced during voluntary abdominal breathing in an eyes-closed condition. Neurosci Res. 2004;50:307–317
  5. Gold PW, Goodwin FK, Chrousos GP. Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress. N Engl J Med. 1988;319:413–420
  6. Hoffman P, Skarphedinsson JO, Delle M, Thoren P. Electrical stimulation of the gastrocnemius muscle in the spontaneously hypertensive rat increases the pain threshold: role of serotonergic receptors. Acta Physiol Scand. 1990;138:125–131
  7. Hugon M. Exteroceptive reflexes to stimulation of the sural nerve in normal man. In:  Desmedt JE editors. Human reflexes pathophysiology of motor systems methodology of human reflexes. New developments in electromyography and clinical neurophysiology. vol. 3:Basel: S. Karger; 1973;p. 713–729
  8. Jacobs BL, Fornal CA. 5-HT and motor control: a hypothesis. Trends Neurosci. 1993;16(9):346–352
  9. Kema IP, De Vries EGE, Muskiet FAJ. Clinical chemistry of serotonin and metabolites. J Chromatogr B. 2000;747:33–48
  10. Kemppainen P, Vaalamo I, Leppala N, Pertovaara A. Changes in tooth pulpal detection and pain thresholds in relation to jaw movement in man. Arch Oral Biol. 2001;46:33–37
  11. Koltyn KF. Analgesia following exercise: a review. Sports Med. 2000;29:85–98
  12. Kremer HPH, Goekoop JG, Van Kempen GMJ. Clinical use of the determination of serotonin in whole blood. J Clin Psychopharm. 1988;10(2):83–87
  13. Lewkowski MD, Barr RG, Sherrard A, Lessard J, Harris AR, Young SN. Effects of chewing gum on responses to routine painful procedures in children. Physiol Behav. 2003;79:257–265
  14. McGinty DJ, Harper RM. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res. 1976;101:569–575
  15. Melzter H. Serotonergic dysfunction in depression. Br J Psychiatry. 1989;155:25–31
  16. Millan MJ. Review: descending control of pain. Prog Neurobiol. 2002;66:355–474
  17. Morley JE, Blundell JE. The neurobiological basis of eating disorders: some formulation. Biol Psychiatry. 1988;23:53–78
  18. Nakata M. Masticatory function and its effects on general health. Int Dent J. 1998;48:540–548
  19. Nakatani Y, Mohri Y, Sato-Suzuki I, Fumoto M, Seki Y, Arita H. Intravenous administration of 5-HTP elevated 5-HT concentration in brain and blood in rat with gastrointestinal resection. Jpn J Physiol. 2004;54(Suppl.):S216
  20. Ogawa A, Morrimoto T, Hu JW, Tashiro A, Noguchi K, Iwata K. Hard-food mastication suppresses complete freund's adjuvant-induced nociception. Neuroscience. 2003;120:1081–1092
  21. Potrebic SB, Fields HL, Mason P. Serotonin immunoreactivity is contained in one physiological cell class in the rat rostral ventromedial medulla. J Neurosci. 1994;14:1655–1665[http://www.jneurosci.org/cgi/reprint/14/3/1655]
  22. Skljarevski V, Ramadan NM. The nociceptive flexion reflex in humans- review article. Pain. 2002;96:3–8
  23. Wakayama K, Ohtsuki S, Takanaga H, Hosoya K, Terasaki T. Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neurosci Res. 2002;44:173–180
  24. Willer JC. Comparative study of perceived pain and nociceptive flexion relex in man. Pain. 1977;3:69–80

PII: S0304-3959(05)00369-6

doi: 10.1016/j.pain.2005.07.009

PAIN
Volume 118, Issue 1 , Pages 35-42 , November 2005