PAIN
Volume 133, Issue 1 , Pages 72-78 , 15 December 2007

Activation of the cortical pain network by soft tactile stimulation after injection of sumatriptan

  • Heidrun H. Krämer

      Affiliations

    • Department of Neurology, Johannes Gutenberg University Mainz, Germany
    • Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Göteborg, Sweden
    • Corresponding Author InformationCorresponding author. Address: University Mainz, Langenbeckstr. 1, 55101 Mainz, Germany. Tel.: +49 6131 175281.
    • ,
  • Linda Lundblad

      Affiliations

    • Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Göteborg, Sweden
    • ,
  • Frank Birklein

      Affiliations

    • Department of Neurology, Johannes Gutenberg University Mainz, Germany
    • ,
  • Mattias Linde

      Affiliations

    • Institute of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg University, Gothenburg, Sweden
    • Cephalea Headache Centre, Gothenburg, Sweden
    • ,
  • Tomas Karlsson

      Affiliations

    • Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Göteborg, Sweden
    • ,
  • Mikael Elam

      Affiliations

    • Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Göteborg, Sweden
    • ,
  • Håkan Olausson

      Affiliations

    • Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Göteborg, Sweden

Received 13 August 2006 ,Revised 14 February 2007 ,Accepted 5 March 2007.

References 

  1. Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain. 2005;9:463–484
  2. Bessou P, Burgess PR, Perl ER, Taylor CB. Dynamic properties of mechanoreceptors with unmyelinated (C) fibers. J Neurophysiol. 1971;34:116–131
  3. Carmichael NM, Charlton MP, Dostrovsky JO. Activation of the peripheral 5-HT1B/D receptor depresses electrically and chemically induced neurogenic inflammation in the rat hindpaw, Society of Neuroscience, the 35th annual meeting, abstract 51.13, session 51., Washington, DC, 2005.
  4. Collins DL, Neelin P, Peters TM, Evans AC. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr. 1994;18:192–205
  5. Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3:655–666
  6. Craig AD, Bushnell MC, Zhang ET, Blomqvist A. A thalamic nucleus specific for pain and temperature sensation. Nature. 1994;372:770–773
  7. Cumberbatch MJ, Hill RG, Hargreaves RJ. Rizatriptan has central antinociceptive effects against durally evoked responses. Eur J Pharmacol. 1997;328:37–40
  8. Dodick DW. Triptans and chest symptoms: the role of pulmonary vasoconstriction. Cephalalgia. 2004;24:298–304
  9. Edin B. Cutaneous afferents provide information about knee joint movements in humans. J Physiol. 2001;531:289–297
  10. Eickhoff SB, Amunts K, Mohlberg H, Zilles K. The human parietal operculum. II. Stereotaxic maps and correlation with functional imaging results. Cereb Cortex. 2006;16:268–279
  11. Essick GK, James A, McGlone FP. Psychophysical assessment of the affective components of non-painful touch. Neuroreport. 1999;10:2083–2087
  12. Goadsby PJ, Edvinsson L. Joint 1994. Wolff Award Presentation. Peripheral and central trigeminovascular activation in cat is blocked by the serotonin (5HT)-1D receptor agonist 311C90. Headache 1994;34:394–399.
  13. Goadsby PJ, Hoskin KL. Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine?. Pain. 1996;67:355–359
  14. Hofbauer RK, Rainville P, Duncan GH, Bushnell MC. Cortical representation of the sensory dimension of pain. J Neurophysiol. 2001;86:402–411
  15. Johansson RS, Vallbo AB. Tactile sensibility in the human hand: relative and absolute densities of four types of mechanoreceptive units in glabrous skin. J Physiol. 1979;286:283–300
  16. Kakuda N. Conduction velocity of low-threshold mechanoreceptive afferent fibers in the glabrous and hairy skin of human hands measured with microneurography and spike-triggered averaging. Neurosci Res. 1992;15:179–188
  17. Kramer H, Wehry R, Rolke R, Birklein F. The influence of zolmitriptan on the axon-reflex mediated neuropeptide release in migraineurs and controls, DGKN, 49. Annual meeting of the German society of clinical neurophysiology, Jena, 2004.
  18. Kringelbach ML. The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 2005;6:691–702
  19. Kumazawa T, Perl ER. Primate cutaneous receptors with unmyelinated (C) fibres and their projection to the substantia gelatinosa. J Physiol (Paris). 1977;73:287–304
  20. Kumazawa T, Perl ER. Primate cutaneous sensory units with unmyelinated (C) afferent fibers. J Neurophysiol. 1977;40:1325–1338
  21. Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci USA. 2004;101:4274–4279
  22. Linde M, Elam M, Lundblad L, Olausson H, Dahlof CG. Sumatriptan (5-HT1B/1D-agonist) causes a transient allodynia. Cephalalgia. 2004;24:1057–1066
  23. Lipton RB, Liberman J, Cutrer FM, Goadsby PJ, Ferrari M, Dodick DW, et al. Treatment preferences and the selection of acute migraine medication: results from a population-based survey. J Headache Pain. 2004;5:123–130
  24. Longmore J, Shaw D, Smith D, Hopkins R, McAllister G, Pickard JD, et al. Differential distribution of 5HT1D- and 5HT1B-immunoreactivity within the human trigemino-cerebrovascular system: implications for the discovery of new antimigraine drugs. Cephalalgia. 1997;17:833–842
  25. Lu Y, Perl ER. A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input. J Neurosci. 2003;23:8752–8758
  26. Nordin M. Low-threshold mechanoreceptive and nociceptive units with unmyelinated (C) fibres in the human supraorbital nerve. J Physiol. 1990;426:229–240
  27. Olausson H, Charron J, Marchand S, Villemure C, Strigo IA, Bushnell MC. Feelings of warmth correlate with neural activity in right anterior insular cortex. Neurosci Lett. 2005;389:1–5
  28. Olausson H, Ha B, Duncan GH, Morin C, Ptito A, Ptito M, et al. Cortical activation by tactile and painful stimuli in hemispherectomized patients. Brain. 2001;124:916–927
  29. Olausson H, Lamarre Y, Backlund H, Morin C, Wallin BG, Starck G, et al. Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci. 2002;5:900–904
  30. Rolls ET, O’Doherty J, Kringelbach ML, Francis S, Bowtell R, McGlone F. Representations of pleasant and painful touch in the human orbitofrontal and cingulate cortices. Cereb Cortex. 2003;13:308–317
  31. Schreckenberger M, Siessmeier T, Viertmann A, Landvogt C, Buchholz HG, Rolke R, et al. The unpleasantness of tonic pain is encoded by the insular cortex. Neurology. 2005;64:1175–1183
  32. Solomon S, Lipton RB, Newman LC. The site of common side effects of sumatriptan. Headache. 1997;37:289–290
  33. Sugiura Y, Lee CL, Perl ER. Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science. 1986;234:358–361
  34. Vallbo A, Olausson H, Wessberg J, Norrsell U. A system of unmyelinated afferents for innocuous mechanoreception in the human skin. Brain Res. 1993;628:301–304
  35. Vallbo AB, Olausson H, Wessberg J. Unmyelinated afferents constitute a second system coding tactile stimuli of the human hairy skin. J Neurophysiol. 1999;81:2753–2763
  36. Varney NR, Benton AL. Tactile perception of direction in relation to handedness and familial handedness. Neuropsychologia. 1975;13:449–454
  37. Villemure C, Bushnell MC. Cognitive modulation of pain: how do attention and emotion influence pain processing?. Pain. 2002;95:195–199
  38. Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci. 2005;6:533–544
  39. Worsley KJ, Liao CH, Aston J, Petre V, Duncan GH, Morales F, et al. A general statistical analysis for fMRI data. Neuroimage. 2002;15:1–15

PII: S0304-3959(07)00114-5

doi: 10.1016/j.pain.2007.03.001

PAIN
Volume 133, Issue 1 , Pages 72-78 , 15 December 2007

Article Tools

* Image Usage & Resolution