PAIN
Volume 134, Issue 1 , Pages 9-15 , January 2008

Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitis

  • QiQi Zhou

      Affiliations

    • Department of Medicine, Division of Gasteroenterology, Hepatology, and Nutrition, University of Florida Colleges of Medicine and Dentistry, 1600 SW Archer Road, HD 602, PO Box 100214, Gainesville, FL 32610-0214, USA
  • ,
  • Donald D. Price

      Affiliations

    • Department of Oral and Maxillofacial Surgery, University of Florida Colleges of Medicine and Dentistry, Gainesville, FL, USA
    • Department of Neuroscience, University of Florida Colleges of Medicine and Dentistry, Gainesville, FL, USA
  • ,
  • Robert M. Caudle

      Affiliations

    • Department of Oral and Maxillofacial Surgery, University of Florida Colleges of Medicine and Dentistry, Gainesville, FL, USA
    • Department of Neuroscience, University of Florida Colleges of Medicine and Dentistry, Gainesville, FL, USA
  • ,
  • G. Nicholas Verne

      Affiliations

    • Department of Medicine, Division of Gasteroenterology, Hepatology, and Nutrition, University of Florida Colleges of Medicine and Dentistry, 1600 SW Archer Road, HD 602, PO Box 100214, Gainesville, FL 32610-0214, USA
    • North Florida/South Georgia VA Medical System, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Medicine, Division of Gasteroenterology, Hepatology, and Nutrition, University of Florida Colleges of Medicine and Dentistry, 1600 SW Archer Road, HD 602, PO Box 100214, Gainesville, FL 32610-0214, USA. Tel.: +1 352 392 2877; fax: +1 352 392 3618.

Received 16 January 2007 ,Revised 19 February 2007 ,Accepted 19 March 2007.

References 

  1. Adam B, Liebregts T, Gschossmann JM, Krippner C, Scholl F, Ruwe M, et al. Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model. Pain. 2006;123:179–186
  2. Al Chaer ED, Kawasaki M, Pasricha PJ. A new model of chronic visceral hypersensitivity in adult rats by colon irritation during postnatal development. Gastroenterology. 2000;119:1276–1285
  3. Bourdu S, Dapoigny M, Chapuy E, Artigue F, Vasson MP, Dechelotte P, et al. Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats. Gastroenterology. 2005;128:1996–2008
  4. Bouin M, Plourde V, Boivin M, Riberdy M, Lupien F, Laganiere M, et al. Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology. 2002;122:1771–1777
  5. Coffin B, Bouhassira D, Sabate JM, Barbe L, Jian R. Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome. Gut. 2004;53:1465–1470
  6. Dubner R. Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury. In: Bond M, Charlton E, Woolf CJ, editors. Proceedings of the 6th World Congress on Pain, Pain Res Clin Manage; 1991;5:263–76.
  7. Dunphy RC, Bridgewater L, Price DD, Robinson ME, Zeilman CJ, Verne GN. Visceral and cutaneous hypersensitivity in Persian Gulf War veterans with chronic gastrointestinal symptoms. Pain. 2003;102:79–85
  8. Gebhart GF. Pathobiology of visceral pain: molecular mechanisms and therapeutic implications. Visceral afferent contributions to the pathobiology of visceral pain. Am J Physiol Gastrointest Liver Physiol. 2000;278:G834–G838
  9. Gwee KA, Graham JC, McKendrick MW, Collins SM, Marshall JS, Walters SJ, et al. Psychometric scores and persistence of irritable bowel after infectious diarrhea. Lancet. 1996;347:150–153
  10. Habler HJ, Janig W, Koltzenburg M. Activation of unmyelinated afferent fibers by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol. 1990;425:545–562
  11. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 1998;32:77–88
  12. Kajander KC, Bennett GJ. Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. J Neurophysiol. 1992;68:734–744
  13. La J-H, Kim T-W, Sung T-S, Kang J-W, Kim H-J, Yang I-S. Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis. World J Gastroenterol. 2003;9:2791–2795
  14. Mayer EA, Raybould HE. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology. 1990;99:1688–1704
  15. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology. 1994;107:271–293
  16. Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, Wallace JL. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology. 1989;96:795–803
  17. Moshiree B, Zhou Q, Price DD, Verne GN. Central sensitization in visceral pain disorders. Gut. 2006;55:905–908
  18. Naliboff BD, Munakata J, Fullerton S, Gracely RH, Kodner A, Harraf F, et al. Evidence for two distinct perceptual alterations in irritable bowel syndrome. Gut. 1997;41:505–512
  19. Ness TJ, Gebhart GF. Colorectal distention as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudoaffective reflexes in the rat. Brain Res. 1998;450:153–169
  20. Price DD, Zhou Q, Moshiree B, Robinson ME, Verne GN. Peripheral and central contribution to hyperalgesia in irritable bowel syndrome. Pain. 2006;7:529–535
  21. Sengupta JN, Gebhart GF. The sensory innervation of the colon. Curr Opin Gastroenterol. 1998;14:15–20
  22. Spiller RC. Postinfectious irritable bowel syndrome. Gastroenterology. 2003;124:1662–1671
  23. Su X, Gebhart GF. Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J Neurophysiol. 1998;80:2632–2644
  24. Verne GN, Robinson ME, Price DD. Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome. Pain. 2001;93:7–14
  25. Verne GN, Himes NC, Robinson ME, Gopinath KS, Briggs RW, Crosson B, et al. Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndrome. Pain. 2003;103:99–110
  26. Wesselmann U, Czakanski PP, Affaitati G, Giamberardino MA. Uterine inflammation as a noxious visceral stimulus: behavioral characterization in the rat. Neurosci Lett. 1998;246:73–76
  27. Zhou Q, Caudle MR, Price DD, Del Valle-Pinero AY, Verne GN. Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats. Mol Pain. 2006;17:2–3
  28. Zhou Q, Stamm P, Price DD, Verne GN. Somatic hypersensitivity in an animal model of IBS. J Pain. 2006;7:S7

PII: S0304-3959(07)00136-4

doi: 10.1016/j.pain.2007.03.029

PAIN
Volume 134, Issue 1 , Pages 9-15 , January 2008