PAIN
Volume 137, Issue 2 , Pages 286-294 , 15 July 2008

Effects of intra-articular ketamine on pain and somatosensory function in temporomandibular joint arthralgia patients

  • Emad E. Ayesh

      Affiliations

    • Department of Clinical Oral Physiology, School of Dentistry, University of Aarhus, Vennelyst Boulevard 9, DK-8000 Aarhus, Denmark
    • ,
  • Troels S. Jensen

      Affiliations

    • Department of Neurology, Aarhus University Hospital, Denmark
    • ,
  • Peter Svensson

      Affiliations

    • Department of Clinical Oral Physiology, School of Dentistry, University of Aarhus, Vennelyst Boulevard 9, DK-8000 Aarhus, Denmark
    • Department of Oral Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark
    • Center for Sensory Motor Interaction, Aalborg University, Denmark
    • Corresponding Author InformationCorresponding author. Tel.: +45 8942 4191; fax: + 45 8619 5665.

Received 26 March 2007 ,Revised 23 August 2007 ,Accepted 5 September 2007.

References 

  1. Alfredson H, Forsgren S, Thorsen K, Lorentzon R. In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper’s knee. J Orthop Res. 2001;19:881–886
  2. Alfredson H, Forsgren S, Thorsen K, Fahlstrom M, Johansson H, Lorentzon R. Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment?. Knee Surg Sports Traumatol Arthrosc. 2001;9:123–126
  3. Arendt-Nielsen L, Petersen-Felix S, Fischer M, Bak P, Bjerring P, Zbinden AM. The effect of N-methyl-d-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study. Anesth Analg. 1995;81:63–68
  4. Arendt-Nielsen L, Nielsen J, Petersen-Felix S, Schnider TW, Zbinden AM. Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain. Br J Anaesth. 1996;77:625–631
  5. Ayesh EE, Jensen TS, Svensson P. Somatosensory function following painful repetitive electrical stimulation of the human temporomandibular joint and skin. Exp Brain Res. 2007;179:415–425
  6. Ayesh EE, Ernberg M, Svensson P. Effects of local anesthetics on somatosensory function in the temporomandibular joint area. Exp Brain Res. 2007;180:715–725
  7. Ayesh EE, Jensen TS, Svensson P. Hypersensitivity in painful temporomandibular joint patients. J Dent Res 2007; in press.
  8. Baad-Hansen L, Juhl GI, Jensen TS, Brandsborg B, Svensson P. Differential effect of intravenous S-ketamine and fentanyl on atypical odontalgia and capsaicin-evoked pain. Pain. 2007;129:46–54
  9. Batra YK, Mahajan R, Bangalia SK, Nagi ON, Dhillon MS. Bupivacaine/ketamine is superior to intra-articular ketamine analgesia following arthroscopic knee surgery. Can J Anaesth. 2005;52:832–836
  10. Berger UV, Carter RE, Coyle JT. The immunocytochemical localization of N-acetylaspartyl glutamate, its hydrolysing enzyme NAALADase, and the NMDAR-1 receptor at a vertebrate neuromuscular junction. Neuroscience. 1995;64:847–850
  11. Bristow A, Orlikowski C. Subcutaneous ketamine analgesia: postoperative analgesia using subcutaneous infusions of ketamine and morphine. Ann R Coll Surg Engl. 1989;71:64–66
  12. Cairns BE, Sessle BJ, Hu JW. Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles. J Neurosci. 1998;18:8056–8064
  13. Cairns BE, Gambarota G, Svensson P, Arendt-Nielsen L, Berde CB. Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience. 2002;109:389–399
  14. Cairns BE, Svensson P, Wang K, Hupfeld S, Graven-Nielsen T, Sessle BJ, et al. Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol. 2003;90:2098–2105
  15. Cairns BE, Svensson P, Wang K, Castrillon E, Hupfeld S, Sessle BJ, et al. Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Exp Brain Res. 2006;169:467–472
  16. Cairns BE. The influence of gender and sex steroids on craniofacial nociception. Headache. 2007;47:319–324
  17. Carlton SM, McNearney TA, Cairns BE. Peripheral glutamate receptors: Novel targets for Analgesics? In: Dostrovsky JO et al., editor. Proceedings of the 10th world congress on pain, progress in pain research and management. Seattle: IASP Press, 2003. pp. 125–139.
  18. Carlton SM, Hargett GL, Coggeshall RE. Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. Neurosci Lett. 1995;197:25–28
  19. Carlton SM, Coggeshall RE. Inflammation-induced changes in peripheral glutamate receptor populations. Brain Res. 1999;820:63–70
  20. Castrillon EE, Cairns BE, Ernberg M, Wang K, Sessle BJ, Arendt-Nielsen L, et al. Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women. J Orofac Pain. 2007;21:216–224
  21. Chen JJ, Johnson EJ. Targeting the bradykinin B1 receptor to reduce pain. Expert Opin Ther Targets. 2007;11:21–35
  22. Curatolo M, Petersen-Felix S, Arendt-Nielsen L. Sensory assessment of regional analgesia in humans: a review of methods and applications. Anesthesiology. 2000;93:1517–1530
  23. Dal D, Tetik O, Altunkaya H, Tetik O, Doral MN. The efficacy of intra-articular ketamine for postoperative analgesia in outpatient arthroscopic surgery. Arthroscopy. 2004;20:300–305
  24. Dong XD, Mann MK, Sessle BJ, Arendt-Nielsen L, Svensson P, Cairns BE. Sensitivity of rat temporalis muscle afferent fibers to peripheral N-methyl-d-aspartate receptor activation. Neuroscience. 2006;141:939–945
  25. Dworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J Craniomandib Disord. 1992;6:301–355
  26. Finnerup NB, Jensen TS. Mechanisms of disease: mechanism-based classification of neuropathic pain-a critical analysis. Nat Clin Pract Neurol. 2006;2:107–115
  27. Fiorentino PM, Cairns BE, Hu JW. Development of inflammation after application of mustard oil or glutamate to the rat temporomandibular joint. Arch Oral Biol. 1999;44:27–32
  28. Frenkel C, Urban BW. Molecular actions of racemic ketamine on human CNS sodium channels. Br J Anaesth. 1992;69:292–297
  29. Gammaitoni A, Gallagher RM, Welz-Bosna M. Topical ketamine gel: possible role in treating neuropathic pain. Pain Med. 2000;1:97–100
  30. Gazerani P, Wang K, Cairns BE, Svensson P, Arendt-Nielsen L. Effects of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women. Pain. 2006;124:338–348
  31. Gottrup H, Bach FW, Jensen TS. Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans. Clin Physiol Funct Imaging. 2004;24:103–108
  32. Graven-Nielsen T, Aspegren KS, Henriksson KG, Bengtsson M, Sorensen J, Johnson A, et al. Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients. Pain. 2000;85:483–491
  33. Hill RG, Oliver KR. Neuropeptide and kinin antagonists. Handb Exp Pharmacol. 2007;181–216
  34. Huang GS, Yeh CC, Kong SS, Lin TC, Ho ST, Wong CS. Intra-articular ketamine for pain control following arthroscopic knee surgery. Acta Anaesthesiol Sin. 2000;38:131–136
  35. Islas JA, Astorga J, Laredo M. Epidural ketamine for control of postoperative pain. Anesth Analg. 1985;64:1161–1162
  36. Jensen TS, Gottrup H, Kasch H, Nikolajsen L, Terkelsen AJ, Witting N. Has basic research contributed to chronic pain treatment?. Acta Anaesthesiol Scand. 2001;45:1128–1135
  37. Jensen TS, Baron R. Translation of symptoms and signs into mechanisms in neuropathic pain. Pain. 2003;102:1–8
  38. Kim HK, Schattschneider J, Lee I, Chung K, Baron R, Chung JM. Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. Pain. 2007;129:93–101
  39. Klein T, Magerl W, Nickel U, Hopf HC, SandkÃ1/4hler J, Treede RD. Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system. Neuropharmacology. 2007;52:655–661
  40. Kristensen JD, Svensson B, Gordh T. The NMDA-receptor antagonist CPP abolishes neurogenic ’wind-up pain’ after intrathecal administration in humans. Pain. 1992;51:249–253
  41. Lam DK, Sessle BJ, Cairns BE, Hu JW. Neural mechanisms of temporomandibular joint and masticatory muscle pain: a possible role for peripheral glutamate receptor mechanisms. Pain Res Manag. 2005;10:145–152
  42. Lam DK, Sessle BJ, Cairns BE, Hu JW. Peripheral NMDA receptor modulation of jaw muscle electromyographic activity induced by capsaicin injection into the temporomandibular joint of rats. Brain Res. 2005;1046:68–76
  43. Lawand NB, McNearney T, Westlund KN. Amino acid release into the knee joint: key role in nociception and inflammation. Pain. 2000;86:69–74
  44. List T, Dworkin SF. Comparing TMD diagnoses and clinical findings at Swedish and US TMD centers using research diagnostic criteria for temporomandibular disorders. J Orofac Pain. 1996;10:240–253
  45. List T, Axelsson S, Leijon G. Pharmacologic interventions in the treatment of temporomandibular disorders, atypical facial pain, and burning mouth syndrome. A qualitative systematic review. J Orofac Pain. 2003;17:301–310
  46. Lobbezoo F, Drangsholt M, Peck C, Sato H, Kopp S, Svensson P. Topical review: new insights into the pathology and diagnosis of disorders of the temporomandibular joint. J Orofac Pain. 2004;18:181–191
  47. Mathisen LC, Skjelbred P, Skoglund LA, Oye I. Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. Pain. 1995;61:215–220
  48. Maixner W, Fillingim R, Booker D, Sigurdsson A. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain. Pain. 1995;63:341–351
  49. Maixner W, Fillingim R, Sigurdsson A, Kincaid S, Silva S. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence for altered temporal summation of pain. Pain. 1998;76:71–81
  50. McNearney T, Speegle D, Lawand N, Lisse J, Westlund KN. Excitatory amino acid profiles of synovial fluid from patients with arthritis. J Rheumatol. 2000;27:739–745
  51. McNearney T, Baethge BA, Cao S, Alam R, Lisse JR, Westlund KN. Excitatory amino acids, TNF-alpha, and chemokine levels in synovial fluids of patients with active arthropathies. Clin Exp Immunol. 2004;137:621–627
  52. McRoberts JA, Coutinho SV, Marvizon JC, Grady EF, Tognetto M, Sengupta JN, et al. Role of peripheral N-methyl-d-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology. 2001;120:1737–1748
  53. Menigaux C, Fletcher D, Dupont X, Guignard B, Guirimand F, Chauvin M. The benefits of intraoperative small-dose ketamine on postoperative pain after anterior cruciate ligament repair. Anesth Analg. 2000;90:129–135
  54. Menigaux C, Guignard B, Fletcher D, Sessler DI, Dupont X, Chauvin M. Intraoperative small-dose ketamine enhances analgesia after outpatient knee arthroscopy. Anesth Analg. 2001;93:606–612
  55. Poyhia R, Vainio A. Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia. Clin J Pain. 2006;22:32–36
  56. Rabben T, Skjelbred P, Oye I. Prolonged analgesic effect of ketamine, an N-methyl-d-aspartate receptor inhibitor, in patients with chronic pain. J Pharmacol Exp Ther. 1999;289:1060–1066
  57. Rabben T, Oye I. Interindividual differences in the analgesic response to ketamine in chronic orofacial pain. Eur J Pain. 2001;5:233–240
  58. Rosseland LA, Stubhaug A, Sandberg L, Breivik H. Intra-articular (IA) catheter administration of postoperative analgesics. A new trial design allows evaluation of baseline pain, demonstrates large variation in need of analgesics, and finds no analgesic effect of IA ketamine compared with IA saline. Pain. 2003;104:25–34
  59. Sahara Y, Noro N, Iida Y, Soma K, Nakamura Y. Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons. J Neurosci. 1997;17:6611–6620
  60. Sato K, Kiyama H, Park HT, Tohyama M. AMPA, KA and NMDA receptors are expressed in the rat DRG neurones. Neuroreport. 1993;4:1263–1265
  61. Schaible HG, Schmelz M, Tegeder I. Pathophysiology and treatment of pain in joint disease. Adv Drug Deliv Rev. 2006;58:323–342
  62. Schnoebel R, Wolff M, Peters SC, Brau ME, Scholz A, Hempelmann G, et al. Ketamine impairs excitability in superficial dorsal horn neurones by blocking sodium and voltage-gated potassium currents. Br J Pharmacol. 2005;146:826–833
  63. Schulte H, Graven-Nielsen T, Sollevi A, Jansson Y, Arendt-Nielsen L, Segerdahl M. Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers. Acta Anaesthesiol Scand. 2003;47:1020–1030
  64. Steenland HW, Ko SW, Wu LJ, Zhuo M. Hot receptors in the brain. Mol Pain. 2006;2:34
  65. Svensson P, Graven-Nielsen T, Arendt-Nielsen L. Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles. Pain. 1998;74:93–100
  66. Vranken JH, Troost D, de HP, Pennings FA, vand V, Dijkgraaf MG, et al. Severe toxic damage to the rabbit spinal cord after intrathecal administration of preservative-free S(+)-ketamine. Anesthesiology. 2006;105:813–818
  67. Wallace MS. Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain. Expert Rev Neurother. 2006;6:1423–1428
  68. Warncke T, Jorum E, Stubhaug A. Local treatment with the N-methyl-d-aspartate receptor antagonist ketamine, inhibit development of secondary hyperalgesia in man by a peripheral action. Neurosci Lett. 1997;227:1–4
  69. Wood JN. Ion channels in analgesia research. Handb Exp Pharmacol. 2007;329–358
  70. Xu M, Kim CJ, Neubert MJ, Heinricher MM. NMDA receptor-mediated activation of medullary pro-nociceptive neurons is required for secondary thermal hyperalgesia. Pain. 2007;127:253–262
  71. Yap AU, Dworkin SF, Chua EK, List T, Tan KB, Tan HH. Prevalence of temporomandibular disorder subtypes, psychologic distress, and psychosocial dysfunction in Asian patients. J Orofac Pain. 2003;17:21–28
  72. Yu XM, Sessle BJ, Haas DA, Izzo A, Vernon H, Hu JW. Involvement of NMDA receptor mechanisms in jaw electromyographic activity and plasma extravasation induced by inflammatory irritant application to temporomandibular joint region of rats. Pain. 1996;68:169–178
  73. Zapantis G, Csoka I, Csanyi E, Horvath G, Eros I. Evaluation of ketamine systemic absorption from topical preparations. Short Communnication. Acta Biol Hung. 2006;57:387–389

PII: S0304-3959(07)00513-1

doi: 10.1016/j.pain.2007.09.004

PAIN
Volume 137, Issue 2 , Pages 286-294 , 15 July 2008

Article Tools

* Image Usage & Resolution