PAIN
Volume 139, Issue 1 , Pages 63-72 , 30 September 2008

Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury

  • Barbara Namer

      Affiliations

    • Department of Physiology and Pathophysiology, University of Erlangen, Universitätsstr. 17, 91054 Erlangen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 9131 85 22796; fax: +49 9131 85 22497.
    • ,
  • Inge Petter Kleggetveit

      Affiliations

    • Department of Clinical Neurophysiology, Rikshospitalet, Oslo, Norway
    • ,
  • Hermann Handwerker

      Affiliations

    • Department of Physiology and Pathophysiology, University of Erlangen, Universitätsstr. 17, 91054 Erlangen, Germany
    • ,
  • Martin Schmelz

      Affiliations

    • Department of Anesthesiology, Mannheim, University Heidelberg, Germany
    • ,
  • Ellen Jorum

      Affiliations

    • Department of Clinical Neurophysiology, Rikshospitalet, Oslo, Norway

Received 18 September 2007 ,Revised 6 February 2008 ,Accepted 3 March 2008.

References 

  1. Arvesen A, Rosen L, Eltvik LP, Kroese A, Stranden E. Skin microcirculation in patients with sequelae from local cold injuries. Int J Microcirc Clin Exp. 1994;14:335–342
  2. Babes A, Zorzon D, Reid G. Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor. Eur J Neurosci. 2004;20:2276–2282
  3. Bickel A, Kramer HH, Hilz MJ, Birklein F, Neundorfer B, Schmelz M. Assessment of the neurogenic flare reaction in small-fiber neuropathies. Neurology. 2002;59:917–919
  4. Campero M, Serra J, Bostock H, Ochoa JL. Slowly conducting afferents activated by innocuous low temperature in human skin. J Physiol. 2001;535:855–865
  5. Campero M, Serra J, Ochoa JL. C-polymodal nociceptors activated by noxious low temperature in human skin. J Physiol. 1996;497:565–572
  6. Davis KD, Pope GE. Noxious cold evokes multiple sensations with distinct time courses. Pain. 2002;98:179–185
  7. Davis KD, Pope GE, Crawley AP, Mikulis DJ. Neural correlates of prickle sensation: a percept-related fMRI study. Nat Neurosci. 2002;5:1121–1122
  8. de Medinaceli L, Hurpeau J, Merle M, Begorre H. Cold and post-traumatic pain: modeling of the peripheral nerve message. Biosystems. 1997;43:145–167
  9. Facer P, Casula MA, Smith GD, Benham CD, Chessell IP, Bountra C, et al. Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol. 2007;7:11–23
  10. Francis TJ, Golden FS. Non-freezing cold injury: the pathogenesis. J R Nav Med Serv. 1985;71:3–8
  11. Frederick J, Buck ME, Matson DJ, Cortright DN. Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury. Biochem Biophys Res Commun. 2007;358:1058–1064
  12. Fruhstorfer H. Thermal sensibility changes during ischemic nerve block. Pain. 1984;20:355–361
  13. Hatem S, Attal N, Willer JC, Bouhassira D. Psychophysical study of the effects of topical application of menthol in healthy volunteers. Pain. 2006;122:190–196
  14. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004;427:260–265
  15. Katsura H, Obata K, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, et al. Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol. 2006;200:112–123
  16. Kobayashi K, Fukuoka T, Obata K, Yamanaka H, Dai Y, Tokunaga A, et al. Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with a delta/c-fibers and colocalization with trk receptors. J Comp Neurol. 2005;493:596–606
  17. Kramer HH, Schmelz M, Birklein F, Bickel A. Electrically stimulated axon reflexes are diminished in diabetic small fiber neuropathies. Diabetes. 2004;53:769–774
  18. Kreh A, Anton F, Gilly H, Handwerker HO. Vascular reactions correlated with pain due to cold. Exp Neurol. 1984;85:533–546
  19. McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002;416:52–58
  20. Namer B, Seifert F, Handwerker HO, Maihofner C. TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. Neuroreport. 2005;16:955–959
  21. Nealen ML, Gold MS, Thut PD, Caterina MJ. TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat. J Neurophysiol. 2003;90:515–520
  22. Obata K, Katsura H, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, et al. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest. 2005;115:2393–2401
  23. Ochoa JL, Yarnitsky D. The triple cold syndrome. Cold hyperalgesia, cold hypoaesthesia and cold skin in peripheral nerve disease. Brain. 1994;117:185–197
  24. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, et al. A TRP channel that senses cold stimuli and menthol. Cell. 2002;108:705–715
  25. Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, et al. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol. 2006;16:1591–1605
  26. Purdue GF, Hunt JL. Cold injury: a collective review. J Burn Care Rehabil. 1986;7:331–342
  27. Rosen L, Eltvik L, Arvesen A, Stranden E. Local cold injuries sustained during military service in the Norwegian army. Arctic Med Res. 1991;50:159–165
  28. Ruijs AC, Jaquet JB, Daanen HA, Hovius SE. Cold intolerance of the hand measured by the CISS questionnaire in a normative study population. J Hand Surg [Br]. 2006;31:533–536
  29. Schmelz M, Michael K, Weidner C, Schmidt R, Torebjork HE, Handwerker HO. Which nerve fibers mediate the axon reflex flare in human skin?. Neuroreport. 2000;11:645–648
  30. Schmelz M, Schmid R, Handwerker HO, Torebjork HE. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain. 2000;123:560–571
  31. Shafer JC, Thompson AW. Local cold injury; a report of sequelae. AMA Arch Dermatol. 1955;72:335–347
  32. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003;112:819–829
  33. Viana F, de la Pena E, Belmonte C. Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat Neurosci. 2002;5:254–260
  34. Wahren LK, Torebjork E, Jorum E. Central suppression of cold-induced C fibre pain by myelinated fibre input. Pain. 1989;38:313–319
  35. Wasner G, Schattschneider J, Binder A, Baron R. Topical menthol – a human model for cold pain by activation and sensitization of C nociceptors. Brain. 2004;127:1159–1171
  36. Weidner C, Schmelz M, Schmidt R, Hansson B, Handwerker HO, Torebjork HE. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J Neurosci. 1999;19:10184–10190

PII: S0304-3959(08)00133-4

doi: 10.1016/j.pain.2008.03.007

PAIN
Volume 139, Issue 1 , Pages 63-72 , 30 September 2008

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