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PAIN
Volume 138, Issue 3
, Pages 667-680
, 15 September 2008
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons
References
- The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons. Neurosci Lett. 2006;399:51–56
- . Responses of adult human dorsal root ganglion neurons in culture to capsaicin and low pH. Pain. 1996;65:31–38
- . cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron. 2002;35:721–731
- . Cloning and molecular characterization of the rat CB2 cannabinoid receptor. Biochim Biophys Acta. 2002;1576:255–264
- . Effect of CP55,940 on mechanosensory spinal neurons following chronic inflammation. Neurosci Lett. 2007;414:105–109
- . CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain. 2002;96:253–260
- . The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. 2004;3:771–784
- . Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naive rats and in rat models of inflammatory and neuropathic pain. Eur J Neurosci. 2004;20:2311–2320
- Discovery of 2-2,4-dichlorophenylamino-N-tetrahydro2H-pyran-4-ylmethyl-4-trifluoromethyl-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007;50:2597–2600
- Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res. 2006;1071:10–23
- . Localisation of central cannabinoid CB1 receptor messenger RNA in subpopulations of rat dorsal root ganglia: a double-label in situ hybridisation study. Neuroscience. 1999;90:923–931
- Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci USA. 2000;97:6155–6160
- Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci USA. 2003;100:10529–10533
- CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. PNAS. 2005;102:3093–3098
- . Cannabinoid WIN55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem. 2006;281:32879–32890
- Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science. 1999;283:401–404
- CB2 cannabinoid receptor-mediated peripheral antinociception. Pain. 2001;93:239–245
- . Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 1990;346:561–564
- . Molecular characterisation of a peripheral receptor for cannabinoids. Nature. 1993;365:61–65
- . Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. J Neurophysiol. 2004;92:3562–3574
- Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann NY Acad Sci. 2006;1074:514–536
- Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. Br J Pharmacol. 2003;140:261–268
- . Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther. 1997;74:129–180
- . Cannabinoid pharmacology: the first 66 years. Br J Pharmacol. 2006;147:S163–S171
- . The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat. Neuroscience. 2003;120:155–162
- Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. 2003;99:955–960
- . Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes. J Neurochem. 1998;71:1525–1534
- Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes. Histochem Cell Biol. 2006;126:177–187
- Actions of cannabinoid receptor ligands on rat cultured sensory neurons: implications for antinociception. Neuropharmacology. 2001;40:221–232
- . Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats. Eur J Neurosci. 2005;22:371–379
- TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature. 2002;418:186–190
- . Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibres and adnexal structures in human skin. J Dermatol Sci. 2005;38:177–188
- . Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev. 1999;51:159–212
- The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron. 1998;21:531–543
- . Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system. Neuroscience. 1989;32:577–580
- . Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neuroscience. 1991;44:131–135
- Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science. 2005;310:329–332
- . Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons. Neuroscience. 2005;135:235–245
- Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet. 2001;357:1338–1339
- COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol. 2006;6:12
- . Increased mortality, hypoactivity and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA. 1999;96:5780–5785
PII: S0304-3959(08)00297-2
doi: 10.1016/j.pain.2008.06.007
© 2008 International Association for the Study of Pain. Published by Elsevier Inc. All rights reserved.
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PAIN
Volume 138, Issue 3
, Pages 667-680
, 15 September 2008

