PAIN
Volume 139, Issue 3 , Pages 569-577 , 31 October 2008

The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy

Received 3 March 2008 ,Revised 24 April 2008 ,Accepted 6 June 2008.

References 

  1. Advokat C, Rutherford D. Selective antinociceptive effect of excitatory amino acid antagonists in intact and acute spinal rats. Pharmacol Biochem Behav. 1995;51:855–860
  2. Angst MS, Drover DR, Lotsch J, Ramaswamy B, Naidu S, Wada DR, et al. Pharmacodynamics of orally administered sustained-release hydromorphone in humans. Anesthesiology. 2001;94:63–73
  3. Banik RK, Brennan TJ. Spontaneous discharge and increased heat sensitivity of rat C-fiber nociceptors are present in vitro after plantar incision. Pain. 2004;112:204–213
  4. Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain. 1996;64:493–501
  5. Cumberbatch MJ, Chizh BA, Headley PM. AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmission. Neuroreport. 1994;5:877–880
  6. Doi T, Jurna I. Analgesic effect of intrathecal morphine demonstrated in ascending nociceptive activity in the rat spinal cord an in effectiveness of caerulein and cholecystokinin octapeptide. Brain Res. 1982;234:399–407
  7. Finkel JC, Besch VG, Hergen A, Kakareka J, Pohida T, Melzer JM, et al. Effects of aging on current vocalization threshold in mice measured by a novel nociception assay. Anesthesiology. 2006;105:360–369
  8. Honore P, Rogers SD, Schwei MJ, Salak-Johnson JL, Luger NM, Sabino MC, et al. Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience. 2000;98:585–598
  9. Hunt SP, Mantyh PW. The molecular dynamics of pain control. Nat Rev Neurosci. 2001;2:83–91
  10. Kehlet H, Dahl JB. Anaesthesia, surgery, and challenges in postoperative recovery. Lancet. 2003;362:1921–1928
  11. Kiso T, Nagakura Y, Toya T, Matsumoto N, Tamura S, Ito H, et al. Neurometer measurement of current stimulus threshold in rats. J Pharmacol Exp Ther. 2001;297:352–356
  12. Koga K, Furue H, Rashid MH, Takaki A, Katafuchi T, Yoshimura M. Selective activation of primary afferent fibers evaluated by sine-wave electrical stimulation. Mol Pain. 2005;1:13
  13. Liu S, Kopacz DJ, Carpenter RL. Quantitative assessment of differential sensory nerve block after lidocaine spinal anesthesia. Anesthesiology. 1995;82:60–63
  14. Malkmus SA, Yaksh TL. Intrathecal catheterization and drug delivery in the rat. Methods Mol Med. 2004;99:109–121
  15. Matsumoto M, Inoue M, Hald A, Yamaguchi A, Ueda H. Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test. Mol Pain. 2006;2:16
  16. Matsutomo R, Takebayashi K, Aso Y. Assessment of peripheral neuropathy using measurement of the current perception threshold with the neurometer in patients with type 2 diabetes mellitus. J Int Med Res. 2005;33:442–453
  17. Nagakura Y, Malkmus S, Yaksh TL. Determination of current threshold for paw withdrawal with sine-wave electrical stimulation in rats: effect of drugs and alteration in acute inflammation. Pain. 2008;134:293–301
  18. Nishiyama T, Yaksh TL, Weber E. Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine. Anesthesiology. 1998;89:715–722
  19. Obata H, Li X, Eisenach JC. Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology. 2004;100:1258–1262
  20. Oda M, Kitagawa N, Yang BX, Totoki T, Morimoto M. Quantitative and fiber-selective evaluation of dose-dependent nerve blockade by intrathecal lidocaine in rats. J Pharmacol Exp Ther. 2005;312:1132–1137
  21. Pirec V, Laurito CE, Lu Y, Yeomans DC. The combined effects of N-type calcium channel blockers and morphine on A delta versus C fiber mediated nociception. Anesth Analg. 2001;92:239–243
  22. Pogatzki EM, Gebhart GF, Brennan TJ. Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incision. J Neurophysiol. 2002;87:721–731
  23. Pogatzki-Zahn EM, Shimizu I, Caterina M, Raja SN. Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain. Pain. 2005;115:296–307
  24. Power I, McCormack J. Postoperative pain management: new, convenient analgesic therapies. Expert Opin Pharmacother. 2007;8:391–399
  25. Rathmell JP, Lair TR, Nauman B. The role of intrathecal drugs in the treatment of acute pain. Anesth Analg. 2005;101:S30–S43
  26. Sakai T, Tomiyasu S, Yamada H, Sumikawa K. Evaluation of allodynia and pain associated with postherpetic neuralgia using current perception threshold testing. Clin J Pain. 2006;22:359–362
  27. Sakura S, Sumi M, Yamada Y, Saito Y, Kosaka Y. Quantitative and selective assessment of sensory block during lumbar epidural anaesthesia with 1% or 2% lidocaine. Br J Anaesth. 1998;81:718–722
  28. Stanfa LC, Dickenson AH. The role of non-N-methyl-d-aspartate ionotropic glutamate receptors in the spinal transmission of nociception in normal animals and animals with carrageenan inflammation. Neuroscience. 1999;93:1391–1398
  29. Zahn PK, Brennan TJ. Lack of effect of intrathecally administered N-methyl-d-aspartate receptor antagonists in a rat model for postoperative pain. Anesthesiology. 1998;88:143–156
  30. Zahn PK, Brennan TJ. Primary and secondary hyperalgesia in a rat model for human postoperative pain. Anesthesiology. 1999;90:863–872
  31. Zahn PK, Gysbers D, Brennan TJ. Effect of systemic and intrathecal morphine in a rat model of postoperative pain. Anesthesiology. 1997;86:1066–1077
  32. Zahn PK, Pogatzki-Zahn EM, Brennan TJ. Spinal administration of MK-801 and NBQX demonstrates NMDA-independent dorsal horn sensitization in incisional pain. Pain. 2005;114:499–510
  33. Zahn PK, Umali E, Brennan TJ. Intrathecal non-NMDA excitatory amino acid receptor antagonists inhibit pain behaviors in a rat model of postoperative pain. Pain. 1998;74:213–223

PII: S0304-3959(08)00324-2

doi: 10.1016/j.pain.2008.06.014

PAIN
Volume 139, Issue 3 , Pages 569-577 , 31 October 2008

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