PAIN
Volume 141, Issue 1 , Pages 19-24 , January 2009

Efficient assessment of neuropathic pain drugs in patients with small fiber sensory neuropathies

  • T.W. Ho

      Affiliations

    • Merck & Co., Inc., UG4C-96 P.O. Box 100, North Wales, PA 19454, USA
    • Corresponding Author InformationCorresponding authors. Tel.: +1 4105022909; fax: +1 4105025560.
  • ,
  • M. Backonja

      Affiliations

    • Department of Neurology, Anesthesiology, Rehabilitation Medicine, University of Wisconsin, Madison, WI, USA
  • ,
  • J. Ma

      Affiliations

    • Merck & Co., Inc., UG4C-96 P.O. Box 100, North Wales, PA 19454, USA
  • ,
  • H. Leibensperger

      Affiliations

    • Merck & Co., Inc., UG4C-96 P.O. Box 100, North Wales, PA 19454, USA
  • ,
  • S. Froman

      Affiliations

    • Merck & Co., Inc., UG4C-96 P.O. Box 100, North Wales, PA 19454, USA
  • ,
  • M. Polydefkis

      Affiliations

    • Department of Neurology, The Johns Hopkins School of Medicine, 1550 Orleans Street, Room 351, Baltimore, MD 21231, USA
    • Corresponding Author InformationCorresponding authors. Tel.: +1 4105022909; fax: +1 4105025560.

Received 11 January 2008 ,Revised 2 July 2008 ,Accepted 14 July 2008.

References 

  1. Adams CP, Brantner VV. Estimating the cost of new drug development: is it really 802 million dollars?. Health Aff [Project Hope]. 2006;25:420–428
  2. Backonja M, Glanzman RL. Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. Clin Ther. 2003;25:81–104
  3. Dworkin RH, Corbin AE, Young JP, Sharma U, LaMoreaux L, Bockbrader H, et al. Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology. 2003;60:1274–1283
  4. Finnerup NB, Otto M, McQuay HJ, Jensen TS, Sindrup SH. Algorithm for neuropathic pain treatment: an evidence based proposal. Pain. 2005;118:289–305
  5. Goldstein DJ, Lu Y, Detke MJ, Lee TC, Iyengar S. Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain. 2005;116:109–118
  6. Holland NR, Crawford TO, Hauer P, Cornblath DR, Griffin JW, McArthur JC. Small-fiber sensory neuropathies: clinical course and neuropathology of idiopathic cases. Ann Neurol. 1998;44:47–59
  7. Holland NR, Stocks A, Hauer P, Cornblath DR, Griffin JW, McArthur JC. Intraepidermal nerve fiber density in patients with painful sensory neuropathy. Neurology. 1997;48:708–711
  8. Khan A, Detke M, Khan SR, Mallinckrodt C. Placebo response and antidepressant clinical trial outcome. J Nerv Ment Dis. 2003;191:211–218
  9. Lacomis D. Small-fiber neuropathy. Muscle Nerve. 2002;26:173–188
  10. Lesser H, Sharma U, LaMoreaux L, Poole RM. Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial. Neurology. 2004;63:2104–2110
  11. Odrcich M, Bailey JM, Cahill CM, Gilron I. Chronobiological characteristics of painful diabetic neuropathy and postherpetic neuralgia: diurnal pain variation and effects of analgesic therapy. Pain. 2006;120:207–212
  12. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial [see comments]. Jama. 1998;280:1837–1842
  13. Rubin DB. Inference and missing data. Biometrika. 1976;63:581–592
  14. Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology. 2003;60:108–111
  15. Turner JA, Deyo RA, Loeser JD, Von Korff M, Fordyce WE. The importance of placebo effects in pain treatment and research. Jama. 1994;271:1609–1614
  16. Vase L, Riley JL, Price DD. A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia. Pain. 2002;99:443–452
  17. Vinik AI, Tuchman M, Safirstein B, Corder C, Kirby L, Wilks K, et al. Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studies. Pain. 2007;128:169–179
  18. Wasan AD, Kaptchuk TJ, Davar G, Jamison RN. The association between psychopathology and placebo analgesia in patients with discogenic low back pain. Pain Med [Malden, Mass]. 2006;7:217–228
  19. Wernicke JF, Pritchett YL, D’Souza DN, Waninger A, Tran P, Iyengar S, et al. A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain. Neurology. 2006;67:1411

 Statistical analysis was performed by J. Ma. All data were made available to the authors.

PII: S0304-3959(08)00402-8

doi: 10.1016/j.pain.2008.07.013

PAIN
Volume 141, Issue 1 , Pages 19-24 , January 2009