PAIN
Volume 144, Issue 1 , Pages 178-186 , July 2009

The c-kit signaling pathway is involved in the development of persistent pain

  • Yan-Gang Sun

      Affiliations

    • Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
    • ,
  • Neilia G. Gracias

      Affiliations

    • Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    • ,
  • Julie Kosto Drobish

      Affiliations

    • Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
    • ,
  • Michael R. Vasko

      Affiliations

    • Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    • ,
  • Robert W. Gereau

      Affiliations

    • Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
    • ,
  • Zhou-Feng Chen

      Affiliations

    • Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
    • Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA
    • Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    • Corresponding Author InformationCorresponding author. Address: Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Received 1 November 2008 ,Revised 4 April 2009 ,Accepted 13 April 2009.

References 

  1. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33:87–107
  2. Besson JM. The neurobiology of pain. Lancet. 1999;353:1610–1615
  3. Brumovsky P, Hygge-Blakeman K, Villar MJ, Watanabe M, Wiesenfeld-Hallin Z, Hokfelt T. Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse – possible implications for pain processing. J Chem Neuroanat. 2006;31:243–262
  4. Cable J, Jackson IJ, Steel KP. Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse. Mech Dev. 1995;50:139–150
  5. Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature. 1988;335:88–89
  6. Chen JJ, Barber LA, Dymshitz J, Vasko MR. Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices. Peptides. 1996;17:31–37
  7. Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, Ericson J, et al. Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci. 2003;6:933–938
  8. Fleischman RA. From white spots to stem cells: the role of the Kit receptor in mammalian development. Trends Genet. 1993;9:285–290
  9. Geissler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell. 1988;55:185–192
  10. Hirata T, Kasugai T, Morii E, Hirota S, Nomura S, Fujisawa H, et al. Characterization of c-kit-positive neurons in the dorsal root ganglion of mouse. Brain Res Dev Brain Res. 1995;85:201–211
  11. Hirata T, Morii E, Morimoto M, Kasugai T, Tsujimura T, Hirota S, et al. Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in dorsal root ganglia of mouse embryos. Development. 1993;119:49–56
  12. Jones SL, Gebhart GF. Spinal pathways mediating tonic, coeruleospinal, and raphe-spinal descending inhibition in the rat. J Neurophysiol. 1987;58:138–159
  13. Jovanovic JN, Czernik AJ, Fienberg AA, Greengard P, Sihra TS. Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci. 2000;3:323–329
  14. Kovacs KJ, Foldes A, Vizi ES. C-kit ligand (stem cell factor) affects neuronal activity, stimulates pituitary–adrenal axis and prolactin secretion in rats. J Neuroimmunol. 1996;65:133–141
  15. Lev S, Blechman JM, Givol D, Yarden Y. Steel factor and c-kit protooncogene: genetic lessons in signal transduction. Crit Rev Oncog. 1994;5:141–168
  16. Lourenssen S, Motro B, Bernstein A, Diamond J. Defects in sensory nerve numbers and growth in mutant Kit and Steel mice. Neuroreport. 2000;11:1159–1165
  17. Malmberg AB, Chen C, Tonegawa S, Basbaum AI. Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science. 1997;278:279–283
  18. Milenkovic N, Frahm C, Gassmann M, Griffel C, Erdmann B, Birchmeier C, et al. Nociceptive tuning by stem cell factor/c-Kit signaling. Neuron. 2007;56:893–906
  19. Miller RJ. Presynaptic receptors. Annu Rev Pharmacol Toxicol. 1998;38:201–227
  20. Motro B, van der KD, Rossant J, Reith A, Bernstein A. Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci. Development. 1991;113:1207–1221
  21. Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI. Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. J Neurosci. 2008;28:7936–7944
  22. Nocka K, Tan JC, Chiu E, Chu TY, Ray P, Traktman P, et al. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J. 1990;9:1805–1813
  23. Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev. 1990;4:390–400
  24. Roskoski R. Structure and regulation of Kit protein-tyrosine kinase – the stem cell factor receptor. Biochem Biophys Res Commun. 2005;338:1307–1315
  25. Rossi P, Sette C, Dolci S, Geremia R. Role of c-kit in mammalian spermatogenesis. J Endocrinol Invest. 2000;23:609–615
  26. Snider WD, McMahon SB. Tackling pain at the source: new ideas about nociceptors. Neuron. 1998;20:629–632
  27. Sun YG, Chen ZF. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature. 2007;448:700–703
  28. Sun YG, Gao YJ, Zhao ZQ, Huang B, Yin J, Taylor GA, et al. Involvement of P311 in the affective, but not in the sensory component of pain. Mol Pain. 2008;4:23
  29. Takagi K, Okuda-Ashitaka E, Mabuchi T, Katano T, Ohnishi T, Matsumura S, et al. Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation. Neuroscience. 2008;153:1278–1288
  30. Zhang SC, Fedoroff S. Cellular localization of stem cell factor and c-kit receptor in the mouse nervous system. J Neurosci Res. 1997;47:1–15
  31. Zhao M, Wang JY, Jia H, Tang JS. Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat. Neuroscience. 2007;144:1486–1494
  32. Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell. 1990;63:213–224
  33. Zylka MJ, Rice FL, Anderson DJ. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005;45:17–25

PII: S0304-3959(09)00217-6

doi: 10.1016/j.pain.2009.04.011

PAIN
Volume 144, Issue 1 , Pages 178-186 , July 2009

Article Tools

* Image Usage & Resolution