PAIN
Volume 145, Issue 1 , Pages 96-104 , September 2009

Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: A randomized, double-blind, placebo-controlled study

  • Roland Staud

      Affiliations

    • Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Medicine, University of Florida, College of Medicine, Gainesville, FL 32610-0221, USA. Tel.: +1 352 273 5345; fax: +1 352 392 8483.
    • ,
  • Susann Nagel

      Affiliations

    • Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    • ,
  • Michael E. Robinson

      Affiliations

    • Department of Clinical & Health Psychology, University of Florida, Gainesville, FL 32610, USA
    • ,
  • Donald D. Price

      Affiliations

    • Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA
    • Department of Oral & Maxillofacial Surgery, University of Florida, Gainesville, FL 32610, USA

Received 24 February 2009 ,Revised 21 May 2009 ,Accepted 21 May 2009.

References 

  1. Arendt-Nielsen L, Graven-Nielsen T. Muscle pain: sensory implications and interaction with motor control. Clin J Pain. 2008;24:291–298
  2. Arendt-Nielsen L, Svensson P. Referred muscle pain: basic and clinical findings. Clin J Pain. 2001;17:11–19
  3. Bajaj P, Bajaj P, Madsen H, Moller M, Arendt-Nielsen L. Antenatal women with or without pelvic pain can be characterized by generalized or segmental hypoalgesia in late pregnancy. J Pain. 2002;3:451–460
  4. Bartels EM, Danneskiold-Samsoe B. Histological abnormalities in muscle from patients with certain types of fibrositis. Lancet. 1986;1:755–757
  5. Bengtsson A. The muscle in fibromyalgia. Rheumatology. 2002;41:721–724
  6. Bengtsson A, Henriksson KG, Larsson J. Muscle biopsy in primary fibromyalgia. Light-microscopical and histochemical findings. Scan J Rheumatol. 1986;15:1–6
  7. Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Giani C, Zbinden AM, Radanov BP. Central hypersensitivity in chronic pain after whiplash injury. Clin J Pain. 2001;17:306–315
  8. Desmeules JA, Cedraschi C, Rapiti E, Baumgartner E, Finckh A, Cohen P, et al. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis Rheum. 2003;48:1420–1429
  9. Devor M. Sodium channels and mechanisms of neuropathic pain. J Pain. 2006;7:S3–S12
  10. Drewes AM, Andreasen A, Schroder HD, Hogsaa B, Jennum P. Pathology of skeletal muscle in fibromyalgia: a histo-immuno-chemical and ultrastructural study. Br J Rheumatol. 1993;32:479–483
  11. Elvin A, Siosteen AK, Nilsson A, Kosek E. Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: a contrast media enhanced colour doppler study. Eur J Pain. 2006;10:137–144
  12. Gracely RH, Lynch SA, Bennett GJ. Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain. 1992;51:175–194
  13. Gracely RH, Petzke F, Wolf JM, Clauw DJ. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum. 2002;46:1333–1343
  14. Hansson P, Ekblom A, Lindblom U, Marchettini P. Does acute intraoral pain alter cutaneous sensibility?. J Neurol Neurosurg Psychiatry. 1988;51:1032–1036
  15. Herren-Gerber R, Weiss S, Arendt-Nielsen L, Petersen-Felix S, Stefano GD, Radanov BP, et al. Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. Pain Med. 2004;5:366–376
  16. Hoheisel U, Koch K, Mense S. Functional reorganization in the rat dorsal horn during an experimental myositis. Pain. 1994;59:111–118
  17. Hong CZ. Lidocaine injection versus dry needling to myofascial trigger point. The importance of the local twitch response. Am J Phys Med Rehabil. 1994;73:256–263
  18. Julien N, Goffaux P, Arsenault P, Marchand S. Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition. Pain. 2005;114:295–302
  19. Kalyan-Raman UP, Kalyan-Raman K, Yunus MB, Masi AT. Muscle pathology in primary fibromyalgia syndrome: a light microscopic, histochemical and ultrastructural study. J Rheumatol. 1984;11:808–813
  20. Kim SH, Jang TJ, Moon IS. Increased expression of N-methyl-d-aspartate receptor subunit 2D in the skin of patients with fibromyalgia. J Rheumatol. 2006;33:785–788
  21. Lapossy E, Maleitzke R, Hrycaj P, Mennet W, Muller W. The frequency of transition of chronic low back pain to fibromyalgia. Scand J Rheumatol. 1995;24:29–33
  22. Li J, Simone DA, Larson AA. Windup leads to characteristics of central sensitization. Pain. 1999;79:75–82
  23. Maixner W, Fillingim R, Booker D, Sigurdsson A. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain. Pain. 1995;63:341–351
  24. Mao J, Price DD, Hayes RL, Lu J, Mayer DJ. Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res. 1992;598:271–278
  25. Okifuji A, Turk DC. Stress and psychophysiological dysregulation in patients with fibromyalgia syndrome. Appl Psychophysiol Biofeedback. 2002;27:129–141
  26. Petzke F, Clauw DJ, Khine A, Gracely RH. Increased pain sensitivity in fibromyalgia: effect of two types of stimuli and ascending versus random modes of presentation. Arthritis Rheum. 2000;43:S173
  27. Pongratz DE, Spath M. Morphologic aspects of fibromyalgia. Z Rheumatol. 1998;57:47–51
  28. Price DD, Bennett GJ, Rafii A. Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block. Pain. 1989;36:273–288
  29. Price DD, Bush FM, Long S, Harkins SW. A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales. Pain. 1994;56:217–226
  30. Price DD, Harkins SW. Combined use of visual analogue scales and experimental pain in providing standardized measurement of clinical pain. Clin J Pain. 1987;3:1–8
  31. Price DD, Long S, Wilsey B, Rafii A. Analysis of peak magnitude and duration of analgesia produced by local anesthetics injected into sympathetic ganglia of complex regional pain syndrome patients. Clin J Pain. 1998;14:216–226
  32. Price DD, McHaffie JG, Larson MA. Spatial summation of heat-induced pain: influence of stimulus area and spatial separation of stimuli on perceived pain sensation intensity and unpleasantness. J Neurophysiol. 1989;62:1270–1279
  33. Price DD, Staud R, Robinson ME, Mauderli AP, Cannon RL, Vierck CJ. Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients. Pain. 2002;99:49–59
  34. Scholz A. Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels. Br J Anaesth. 2002;89:52–61
  35. Sluka KA, Radhakrishnan R, Benson CJ, Eshcol JO, Price MP, Babinski K, et al. ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain. 2007;129:102–112
  36. Smith BW, Tooley EM, Montague EQ, Robinson AE, Cosper CJ, Mullins PG. Habituation and sensitization to heat and cold pain in women with fibromyalgia and healthy controls. Pain. 2008;140:420–428
  37. Staud R. Temporal summation of pain from mechanical stimulation of muscle. In:  Gracely RH,  Choy E editor. Fibromyalgia: about mechanisms. Lavaur, France: Pierre Fabre; 2005;p. 52–57
  38. Staud R, Bovee CE, Robinson ME, Price DD. Cutaneous C-fiber abnormalities of fibromyalgia patients are specifically related to temporal summation. Pain. 2008;139:315–325
  39. Staud R, Cannon RC, Mauderli AP, Robinson ME, Price DD, Vierck CJ. Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome. Pain. 2003;102:87–95
  40. Staud R, Craggs JG, Perlstein WM, Robinson ME, Price DD. Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls. Eur J Pain. 2008;12:1078–1089
  41. Staud R, Price DD, Robinson ME, Mauderli AP, Vierck CJ. Maintenance of windup of second pain requires less frequent stimulation in fibromyalgia patients compared to normal controls. Pain. 2004;110:689–696
  42. Staud R, Price DD, Robinson ME, Vierck CJ. Body pain area and pain-related negative affect predict clinical pain intensity in patients with fibromyalgia. J Pain. 2004;5:338–343
  43. Staud R, Robinson ME, Price DD. Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients. J Pain. 2007;8:893–901
  44. Staud R, Robinson ME, Vierck CJ, Cannon RL, Mauderli AP, Price DD. Ratings of experimental pain and pain-related negative affect predict clinical pain in patients with fibromyalgia syndrome. Pain. 2003;105:215–222
  45. Staud R, Vierck CJ, Cannon RL, Mauderli AP, Price DD. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain. 2001;91:165–175
  46. Staud R, Vierck CJ, Robinson ME, Price DD. Spatial summation of heat pain within and across dermatomes in fibromyalgia patients and pain-free subjects. Pain. 2004;111:342–350
  47. Staud R, Vierck CJ, Robinson ME, Price DD. Effects of the NDMA receptor antagonist dextromethorphen on temporal summation of pain are similar in fibromyalgia patients and normal controls. J Pain. 2005;6:323–332
  48. Staud R, Vierck CJ, Robinson ME, Price DD. Overall fibromyalgia pain is predicted by ratings of local pain and pain related negative affect: possible role of peripheral tissues. Rheumatology. 2006;45:1409–1415
  49. Ushida T, Willis WD. Changes in dorsal horn neuronal responses in an experimental wrist contracture model. J Orthop Sci. 2001;6:46–52
  50. Verne GN, Himes NC, Robinson ME, Gopinath KS, Briggs RW, Crosson B, et al. Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndrome. Pain. 2003;103:99–110
  51. Verne GN, Robinson ME, Vase L, Price DD. Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients. Pain. 2003;105:223–230
  52. Verne GN, Sen A, Price DD. Intrarectal lidocaine is an effective treatment for abdominal pain associated with diarrhea-predominant irritable bowel syndrome. J Pain. 2005;6:493–496
  53. Vierck CJ. Mechanisms underlying development of spatially distributed chronic pain (fibromyalgia). Pain. 2006;124:242–263
  54. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33:160–172
  55. Yunus MB. Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes. Semin Arthritis Rheum. 2007;36:339–356
  56. Zhou Q, Price DD, Verne GN. Reversal of visceral and somatic hypersensitivity in a subset of hypersensitive rats by intracolonic lidocaine. Pain. 2008;139:218–224

PII: S0304-3959(09)00306-6

doi: 10.1016/j.pain.2009.05.020

PAIN
Volume 145, Issue 1 , Pages 96-104 , September 2009

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