PAIN
Volume 145, Issue 3 , Pages 271-272 , October 2009

Ketamine and chronic pain – Going the distance

  • David Borsook

      Affiliations

    • Corresponding Author InformationTel.: +1 617 877 3195; fax: +1 617 855 3772.

Received 13 May 2009 ,Accepted 22 May 2009.

References 

  1. Flor H, Nikolajsen L, Staehelin Jensen T. Phantom limb pain: a case of maladaptive CNS plasticity?. Nat Rev Neurosci. 2006;7:873–881
  2. Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish TB, Apkarian AV. The brain in chronic CRPS pain: abnormal gray–white matter interactions in emotional and autonomic regions. Neuron. 2008;60:570–581
  3. Goldberg ME, Domsky R, Scaringe D, Hirsh R, Dotson J, Sharaf I, et al. Multi-day low dose ketamine infusion for the treatment of complex regional pain syndrome. Pain Physician. 2005;8:175–179
  4. Grachev ID, Thomas PS, Ramachandran TS. Decreased levels of N-acetylaspartate in dorsolateral prefrontal cortex in a case of intractable severe sympathetically mediated chronic pain (complex regional pain syndrome, type I). Brain Cogn. 2002;49:102–113
  5. Hudetz JA, Iqbal Z, Gandhi SD, Patterson KM, Byrne AJ, Hudetz AG, et al. Ketamine attenuates post-operative cognitive dysfunction after cardiac surgery. Acta Anaesthesiol Scand. 2009;
  6. Kiefer RT, Rohr P, Ploppa A, Dieterich HJ, Grothusen J, Koffler S, et al. Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. Pain Med. 2008;9:1173–1201
  7. Kiefer RT, Rohr P, Ploppa A, Nohe B, Dieterich HJ, Grothusen J, et al. A pilot open-label study of the efficacy of subanesthetic isomeric S(+)-ketamine in refractory CRPS patients. Pain Med. 2008;9:44–54
  8. Koffler SP, Hampstead BM, Irani F, Tinker J, Kiefer RT, Rohr P, et al. The neurocognitive effects of 5 day anesthetic ketamine for the treatment of refractory complex regional pain syndrome. Arch Clin Neuropsychol. 2007;22:719–729
  9. Lipton SA. Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer’s disease and other neurologic disorders. J Alzheimers Dis. 2004;6:S61–74
  10. Machado-Vieira R, Salvadore G, Diazgranados N, Zarate Jr CA. Ketamine and the next generation of antidepressants with a rapid onset of action. Pharmacol Ther 2009, in press.
  11. Maihofner C, Baron R, DeCol R, Binder A, Birklein F, Deuschl G, et al. The motor system shows adaptive changes in complex regional pain syndrome. Brain. 2007;130:2671–2687
  12. McGhee LL, Maani CV, Garza TH, Gaylord KM, Black IH. The correlation between ketamine and posttraumatic stress disorder in burned service members. J Trauma 2008;64:S195–8. Discussion S197-198.
  13. Millan MJ. The induction of pain: an integrative review. Prog Neurobiol. 1999;57:1–164
  14. Seifert F, Kiefer G, DeCol R, Schmelz M, Maihofner C. Differential endogenous pain modulation in complex-regional pain syndrome. Brain. 2009;132:788–800
  15. Sigtermans MJ, van Hilten JJ, Bauer MCR, Sesmu Arbous M, Marinus J, Sarton EY, et al. Ketamine produces effective and long-term pain relief in patients with complex regional pain syndrome type 1. Pain. 2009;145:304–311
  16. Snyder GL, Galdi S, Hendrick JP, Hemmings HC. General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology. 2007;53:619–630
  17. Verkhratsky A, Kirchhoff F. NMDA receptors in glia. Neuroscientist. 2007;13:28–37
  18. Visser E, Schug SA. The role of ketamine in pain management. Biomed Pharmacother. 2006;60:341–348
  19. Winkelheide U, Lasarzik I, Kaeppel B, Winkler J, Werner C, Kochs E, et al. Dose-dependent effect of S(+)-ketamine on post-ischemic endogenous neurogenesis in rats. Acta Anaesthesiol Scand. 2009;53:528–533

PII: S0304-3959(09)00307-8

doi: 10.1016/j.pain.2009.05.021

PAIN
Volume 145, Issue 3 , Pages 271-272 , October 2009

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