PAIN
Volume 145, Issue 3 , Pages 265-266 , October 2009

Underpowered clinical trials: Time for a change

Received 7 July 2009 ,Accepted 24 July 2009.

References 

  1. Coppes MH, Marani E, Thomeer RT, Groen GJ. Innervation of “painful” lumbar discs. Spine. 1997;22:2342–2349[discussion 2349–50]
  2. Derby R, Howard MW, Grant JM, Lettice JJ, Van Peteghem PK, Ryan DP. The ability of pressure-controlled discography to predict surgical and nonsurgical outcomes. Spine. 1999;24:364–371[discussion 371–62]
  3. Kvarstein G, Måwe L, Indahl A, Hol PK, Tennøe B, Digernes R, et al. A randomised double blind controlled trial of intra-annular radiofrequency thermal disc therapy – a 12 month follow-up. Pain. 2009;145:279–286
  4. Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A. Low back pain in relation to lumbar disc degeneration. Spine. 2000;25:487–492
  5. Miller JA, Schmatz C, Schultz AB. Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens. Spine. 1988;13:173–178
  6. O’Brien PC. Procedures for comparing samples with multiple endpoints. Biometrics. 1984;40:1079–1087
  7. Pauza KJ, Howell S, Dreyfuss P, Peloza JH, Dawson K, Bogduk N. A randomized, placebo-controlled trial of intradiscal electrothermal therapy for the treatment of discogenic low back pain [see comment]. Spine J. 2004;4:27–35
  8. Schellings R, Kessels AG, ter Riet G, Sturmans F, Widdershoven GA, Knottnerus JA. Indications and requirements for the use of prerandomization. J Clin Epidemiol. 2009;62:393–399
  9. Snapinn SM. Monitoring clinical trials with a conditional probability stopping rule. Stat Med. 1992;11:659–672

PII: S0304-3959(09)00418-7

doi: 10.1016/j.pain.2009.07.033

PAIN
Volume 145, Issue 3 , Pages 265-266 , October 2009

Article Tools