« Previous
Next »
PAIN
Volume 148, Issue 1
, Pages 26-35
, January 2010
Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids
References
- . Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci. 2007;10:870–879
- . PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci. 2002;5:34–40
- . Direct activation of rat spinal dorsal horn neurons by prostaglandin E2. J Neurosci. 2001;21:1750–1756
- . Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E (EP1–EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint. J Neurosci. 2004;24:642–651
- . Lipid signals in pain control. Nature. 2002;420:135–138
- . Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. Neuroscience. 2002;142:527–539
- . Antinociceptive effects of TNF-α neutralization in a rat model of antigen-induced arthritis. Arthritis Rheum. 2008;58:2368–2378
- . L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats. Neuropharmacol. 1994;33:1609–1611
- . Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with a ulcerogenic sparing effect in rat and nonhuman primate stomach. J Pharmacol Exp Ther. 1994;274:1531–1537
- . Effect of CB55,940 on mechanosensory spinal neurons following chronic inflammation. Neurosci Lett. 2007;414:105–109
- . Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans. Anesthesiology. 2005;102:409–415
- . Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. J Physiol. 2005;569:751–760
- . Cannabinoid CB(1) receptor expression in at spinal cord. Mol Cell Neurosci. 2000;15:510–521
- . Peripheral analgesic sites of action of anti-inflammatory drugs. Int J Clin Pract. 2002;Suppl. 128:2–10
- . Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. J Neurosci. 2004;24:2727–2732
- . TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 2008;57:746–759
- . Cannabinoid CB2 receptors: immunohistochemical localization in the rat brain. Brain Res. 2006;1071:10–23
- . A role for endocannabinoids in indomethacin-induced spinal antinociception. Eur J Pharmacol. 2002;454:153–163
- . The effect of acetylsalicylate on joint mechanoreceptors in rats with polyarthritis. Exp Brain Res. 1985;61:164–168
- . Effects of acetylsalicylic acid (ASA) and indomethacin on single groups III and IV sensory units from acutely inflamed joints. Pain. 1986;26:337–351
- . Cannabinoid modulation of wide dynamic range neurons in the lumbar dorsal horn of the rat by spinally administered WIN55,212-2. Neurosci Lett. 1998;257:119–122
- . Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra – but not intracellular pH. Naunyn Schmiedebergs Arch Pharmacol. 2003;36737–36744
- . Nonsteroidal anti-inflammatory drugs increase expression of inducible COX-2 isoform of cyclooxygenase in spinal cord of rats with adjuvant induced inflammation. Mol Brain Res. 2004;125:113–119
- . Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia. J Neurochem. 2003;86:318–328
- . The actions of anandamide on rat superficial medullary dorsal horn neurons in vitro. J Physiol. 2003;548:121–129
- . Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. Br J Pharmacol. 2007;152:624–632
- . Cyclooxygenases and the central nervous system. Prostaglandins. 1997;54:601–624
- . COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci USA. 1996;93:2317–2321
- . Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. Nat Neurosci. 2004;7:697–698
- . Oxidative metabolism of endocannabinoids. Prostaglandins Leukot Essent Fatty Acids. 2002;66:211–220
- . Oxidative metabolism of endocannabinoids by COX-2. Curr Pharm Des. 2004;10:659–667
- . The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or non-selective inhibitors on pain behavior and spinal Fos-like immunoreactivity. Anesth Analg. 2008;106:972–977
- . Function of COX-2 and prostaglandins in neurological disease. J Mol Neurosci. 2007;33:94–99
- . Spinal and supraspinal components of cannabinoid-induced antinociception. J Pharmacol Exp Ther. 1991;258:517–523
- . Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. Brain Res. 2002;937:94–99
- . Localization and regulation of cyclooxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord. Neuroscience. 2000;101:1093–1108
- . Role of COX-2 in inflammatory and degenerative brain diseases. Subcell Biochem. 2007;42:127–141
- . The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol Psychiatry. 2006;11:680–684
- . N-Methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat’s knee joint. J Neurophysiol. 1993;70:1365–1377
- . Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons. Eur J Neurosci. 1994;6:1179–1186
- . Calcitonin gene-related peptide is involved in the generation and maintenance of hyperexcitability of dorsal horn neurons observed during development of acute inflammation in rat’s knee joint. Neuroscience. 1996;71:1095–1109
- . The involvement of substance P and neurokinin-1 receptors in the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat’s knee joint. J Neurophysiol. 1995;73:1574–1583
- . Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes. J Biochem (Tokyo). 2007;141:687–697
- . Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann N Y Acad Sci. 2006;1074:514–536
- . Antihyperalgesic effects of spinal cannabinoids. Eur J Pharmacol. 1998;345:145–153
- . Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia. J Neurosci. 1998;18:451–457
- . Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography–tandem electrospray ionization mass spectrometry. Anal Biochem. 2007;360:216–226
- . Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord. Neurosci Lett. 2002;329:13–16
- . CB1-cannabinoid and mu-opioid receptor co-localization on postsynaptic target in rat dorsal horn. Neuroreport. 2001;12:3689–3692
- . Interleukin-1β-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature. 2001;410:471–475
- . Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurones of rats. Arthritis Res. 2000;2:424–427
- . Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus. Neuropharmacology. 2005;49:653–659
- . Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci USA. 1998;95:13313–13318
- . The spinal phospholipase-prostanoid cascade in nociceptive processing. Annu Rev Toxicol. 2002;42:553–583
- . Effects of selective COX-1 and COX-2 inhibition on formalin-evoked nociceptive behavior and prostaglandin E2 release in the spinal cord. J Biochem. 2001;79:777–786
- . Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem. 2004;271:1827–1834
- . Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 1971;231:232–235
- . Prostaglandins and cyclooxygenases in the spinal cord. Prog Neurobiol. 2001;64:327–363
- . Spinal prostaglandins are involved in the development but not the maintenance of inflammation-induced spinal hyperexcitability. J Neurosci. 2001;21:9001–9008
- . Prostanoids synthesized by cyclooxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability. Br J Pharmacol. 1997;122:1593–1604
- . Neuronal plasticity: increasing the gain in pain. Science. 2000;288:1765–1768
- . Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron. 1993;11:371–386
- . Analysis of the effects of cyclooxygenase COX-1 and COX-2 spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS398, a COX-2 selective inhibitor. Brain Res. 1996;739:104–110
- . Analysis of the roles of cyclooxygenase COX-1 and COX-2 in spinal nociceptive transmission. Progr Pain Res Manag. 1997;8:303–312
- . Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models. Eur J Neurosci. 2003;17:2750–2754
- . Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain. Anesth Analg. 2005;100:1390–1393
PII: S0304-3959(09)00460-6
doi: 10.1016/j.pain.2009.08.013
© 2009 International Association for the Study of Pain. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
PAIN
Volume 148, Issue 1
, Pages 26-35
, January 2010

