PAIN
Volume 147, Issue 1 , Pages 7-8 , 15 December 2009

Understanding the mechanisms of cold-evoked pain in humans

Received 17 August 2009 ,Accepted 18 August 2009.

References 

  1. Attal N, Bouhassira D, Gautron M, Vaillant JN, Mitry E, Lepère C, et al. Thermal hyperalgesia as a marker of oxaliplatin neurotoxicity: a prospective quantified sensory assessment study. Pain. 2009;144:245–252
  2. Belmonte C, Brock JA, Viana F. Converting cold into pain. Exp Brain Res. 2009;196:13–30
  3. Green BG. The sensory effects of l-menthol on human skin. Somatosens Mot Res. 1992;9:235–244
  4. Hagbarth E. Microelectrode recordings from human peripheral nerves. Muscle Nerve. 2002;11:S28–S35
  5. Katsura H, Obata K, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, et al. Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol. 2006;200:112–123
  6. Madrid R, de la Peña E, Donovan-Rodriguez T, Belmonte C, Viana F. Variable threshold of cold-sensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels. J Neurosci. 2009;29:3120–3131
  7. McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002;416:52–58
  8. Namer B, Kleggetveit IP, Handwerker H, Schmelz M, Jorum E. Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury. Pain. 2008;139:63–72
  9. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, et al. A TRP channel that senses cold stimuli and menthol. Cell. 2002;108:705–715
  10. Schäfer K, Braun H, Isenberg C. Effect of menthol on cold receptor activity. Analysis of receptor processes. J Gen Physiol. 1986;88:757–776
  11. Schmelz M. Itch and cold allodynia. In:  Cervero F editors. Handbook of clinical neurology: pain. vol. 2:Elsevier Science; 2006;p. 249–260
  12. Serra J, Solá R, Quiles C, Casanova-Molla J, Pascual V, Bostock H, et al. C-nociceptors sensitized to cold in a patient with small fiber neuropathy and cold allodynia. Pain. 2009;147:46–53
  13. Staaf S, Oerther S, Lucas G, Mattsson JP, Ernfors P. Differential regulation of TRP channels in a rat model of neuropathic pain. Pain. 2009;144:187–199
  14. Zimmermann K, Leffler A, Babes A, Cendan CM, Carr RW, Kobayashi J, et al. Sensory neuron sodium channel Nav1. 8 is essential for pain at low temperatures. Nature. 2007;447:856–859
  15. Wasner G, Schattschneider J, Binder A, Baron R. Topical menthol–a human model for cold pain by activation and sensitization of C nociceptors. Brain. 2004;127:1159–1171
  16. Xiao B, Dubin AE, Bursulaya B, Viswanath V, Jegla TJ, Patapoutian A. Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci. 2008;28:9640–9651

PII: S0304-3959(09)00462-X

doi: 10.1016/j.pain.2009.08.012

PAIN
Volume 147, Issue 1 , Pages 7-8 , 15 December 2009

Article Tools