Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

Gao, BaoXi; Hierl, Markus; Clarkin, Kristie; Juan, Todd; Nguyen, Hung; Valk, Marissa van der; Deng, Hong; Guo, Wenhong; Lehto, Sonya G.; Matson, David; McDermott, Jeff S.; Knop, Johannes; Gaida, Kevin; Cao, Lei; Waldon, Dan; Albrecht, Brian K.; Boezio, Alessandro A.; Copeland, Katrina W.; Harmange, Jean-Christophe; Springer, Stephanie K.; Malmberg, Annika B.; McDonough, Stefan I.

doi:10.1016/j.pain.2010.01.007

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Volume 149, Issue 1 , Pages 33-49, April 2010

Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

BaoXi Gao
- Department of Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
- These authors contributed equally to this work.
Markus Hierl
- Department of Neuroscience, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
- Department of Lead Discovery, Amgen, Inc., Josef-Engert-St. 11, D-93053 Regensburg, Germany
- These authors contributed equally to this work.
Kristie Clarkin
- Department of Protein Sciences, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
Todd Juan
- Department of Protein Sciences, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
Hung Nguyen
- Department of Protein Sciences, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
Marissa van der Valk
- Department of Protein Sciences, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
Hong Deng
- Department of Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
Wenhong Guo
- Department of Neuroscience, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Sonya G. Lehto
- Department of Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
David Matson
- Department of Neuroscience, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Jeff S. McDermott
- Department of Neuroscience, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
- Department of Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
Johannes Knop
- Department of Lead Discovery, Amgen, Inc., Josef-Engert-St. 11, D-93053 Regensburg, Germany
Kevin Gaida
- Department of Inflammation, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
Lei Cao
- Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Dan Waldon
- Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Brian K. Albrecht
- Department of Chemistry Research and Development, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Alessandro A. Boezio
- Department of Chemistry Research and Development, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Katrina W. Copeland
- Department of Chemistry Research and Development, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Jean-Christophe Harmange
- Department of Chemistry Research and Development, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Stephanie K. Springer
- Department of Chemistry Research and Development, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Annika B. Malmberg
- Department of Neuroscience, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
Stefan I. McDonough
- Department of Neuroscience, Amgen, Inc., 360 Binney Street, Cambridge MA 02142, USA
- Department of Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks CA 91320, USA
- Corresponding author. Tel.: +1 617 444 5580; fax: +1 617 494 1075.