PAIN
Volume 149, Issue 1 , Pages 64-70 , April 2010

Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain

  • Clas Linnman

      Affiliations

    • Department of Psychology, Uppsala University, Uppsala, Sweden
    • Corresponding Author InformationCorresponding author. Address: 7 Grove Street, apt 9, Boston, MA 02114, USA. Tel.: +1 857 284 28 16; fax: +1 617 726 4029.
    • ,
  • Lieuwe Appel

      Affiliations

    • Uppsala Imanet AB, GE Healthcare, Uppsala, Sweden
    • ,
  • Tomas Furmark

      Affiliations

    • Department of Psychology, Uppsala University, Uppsala, Sweden
    • ,
  • Anne Söderlund

      Affiliations

    • Department of Physiotherapy, School of Health, Care and Social Welfare, Mälardalen University, Västerås, Sweden
    • Section of Physiotherapy, Department of Neuroscience, Uppsala University, Sweden
    • ,
  • Torsten Gordh

      Affiliations

    • Laboratory of Pain Research, Department of Surgical Sciences, Division of Anaesthesiology and Intensive Care Medicine, Uppsala University Hospital, Sweden
    • ,
  • Bengt Långström

      Affiliations

    • Department of Biochemistry and Organic Chemistry, Uppsala University, Sweden
    • Neuropsychopharmacology Section, Faculty of Medicine, Imperial College, London, UK
    • ,
  • Mats Fredrikson

      Affiliations

    • Department of Psychology, Uppsala University, Uppsala, Sweden

Received 9 August 2009 ,Revised 30 December 2009 ,Accepted 12 January 2010.

References 

  1. Alpar E‘, Onuoha G, Killampalli VV, Waters R. Management of chronic pain in whiplash injury. J Bone Joint Surg. 2002;84:807–811
  2. An X, Bandler R, Ongur D, Price JL. Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in macaque monkeys. J Comp Neurol. 1998;401:455–479
  3. Apkarian AV, Baliki MN, Geha PY. Towards a theory of chronic pain. Prog Neurobiol. 2009;87:81–97
  4. Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain (Lond, England). 2005;9:463–484
  5. Baliki MN, Chialvo DR, Geha PY, Levy RM, Harden RN, Parrish TB, et al. Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain. J Neurosci. 2006;26:12165–12173
  6. Baliki MN, Geha PY, Apkarian AV, Chialvo DR. Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. J Neurosci. 2008;28:1398–1403
  7. Bergström M, Fasth KJ, Kilpatrick G, Ward P, Cable KM, Wipperman MD, et al. Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171--PET studies in rhesus monkey. Neuropharmacology. 2000;39:664–670
  8. Blomeley CP, Kehoe LA, Bracci E. Substance P mediates excitatory interactions between striatal projection neurons. J Neurosci. 2009;29:4953–4963
  9. Carmichael ST, Price JL. Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys. J Comp Neurol. 1996;371:179–207
  10. Crombez G, Vlaeyen JW, Heuts PH, Lysens R. Pain-related fear is more disabling than pain itself: evidence on the role of pain-related fear in chronic back pain disability. Pain. 1999;80:329–339
  11. de Lange RP, Wiegant VM, Stam R. Altered neuropeptide Y and neurokinin messenger RNA expression and receptor binding in stress-sensitised rats. Brain Res. 2008;1212:35–47
  12. Duric V, McCarson KE. Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain. Mol Pain. 2007;3:32
  13. Elliott PJ, Iversen SD. Behavioural effects of tachykinins and related peptides. Brain Res. 1986;381:68–76
  14. Freedman LJ, Insel TR, Smith Y. Subcortical projections of area 25 (subgenual cortex) of the macaque monkey. J Comp Neurol. 2000;421:172–188
  15. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ. Psychophysiological and modulatory interactions in neuroimaging. NeuroImage. 1997;6:218–229
  16. Friston KJ, Holmes AP, Worsley KJ, Poline JP, Frith CD, Frackowiak RSJ. Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp. 1994;2:189–210
  17. Fujimura Y, Yasuno F, Farris A, Liow JS, Geraci M, Drevets W, et al. Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ. Biol Psychiatry. 2009;66:94–97
  18. Geha PY, Baliki MN, Harden RN, Bauer WR, Parrish TB, Apkarian AV. The brain in chronic CRPS pain: abnormal gray–white matter interactions in emotional and autonomic regions. Neuron. 2008;60:570–581
  19. Gracely RH, Geisser ME, Giesecke T, Grant MA, Petzke F, Williams DA, et al. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain. 2004;127:835–843
  20. Grady EF, Garland AM, Gamp PD, Lovett M, Payan DG, Bunnett NW. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995;6:509–524
  21. Gundel H, Valet M, Sorg C, Huber D, Zimmer C, Sprenger T, et al. Altered cerebral response to noxious heat stimulation in patients with somatoform pain disorder. Pain. 2008;137:413–421
  22. Haber SN, Kunishio K, Mizobuchi M, Lynd-Balta E. The orbital and medial prefrontal circuit through the primate basal ganglia. J Neurosci. 1995;15:4851–4867
  23. Hasenohrl RU, Souza-Silva MA, Nikolaus S, Tomaz C, Brandao ML, Schwarting RK, et al. Substance P and its role in neural mechanisms governing learning, anxiety and functional recovery. Neuropeptides. 2000;34:272–280
  24. Hietala J, Nyman MJ, Eskola O, Laakso A, Gronroos T, Oikonen V, et al. Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain. Mol Imaging Biol. 2005;7:262–272
  25. Hill R. NK1 (substance P) receptor antagonists – why are they not analgesic in humans?. Trends Pharmacol Sci. 2000;21:244–246
  26. Kafetzopoulos E, Holzhauer MS, Huston JP. Substance P injected into the region of the nucleus basalis magnocellularis facilitates performance of an inhibitory avoidance task. Psychopharmacology. 1986;90:281–283
  27. Kertes E, Laszlo K, Berta B, Lenard L. Effects of substance P microinjections into the globus pallidus and central nucleus of amygdala on passive avoidance learning in rats. Behav Brain Res. 2009;198:397–408
  28. Lenard L, Kertes E. Influence of passive avoidance learning by substance P in the basolateral amygdala. Acta Biol Hung. 2002;53:95–104
  29. Linnman C, Appel L, Soderlund A, Frans O, Engler H, Furmark T, et al. Chronic whiplash symptoms are related to altered regional cerebral blood flow in the resting state. Eur J Pain (Lond, England). 2009;13:65–70
  30. Lutz J, Jager L, de Quervain D, Krauseneck T, Padberg F, Wichnalek M, et al. White and gray matter abnormalities in the brain of patients with fibromyalgia: a diffusion-tensor and volumetric imaging study. Arthritis Rheum. 2008;58:3960–3969
  31. Mai JK, Assheuer J, Paxinos G. Atlas of the human brain. San Diego: Academic Press; 1997;
  32. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage. 2003;19:1233–1239
  33. May A. Chronic pain may change the structure of the brain. Pain. 2008;137:7–15
  34. McFarland NR, Haber SN. Thalamic relay nuclei of the basal ganglia form both reciprocal and nonreciprocal cortical connections, linking multiple frontal cortical areas. J Neurosci. 2002;22:8117–8132
  35. Michelgard A, Appel L, Pissiota A, Frans O, Langstrom B, Bergstrom M, et al. Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system. Biol Psychiatry. 2007;61:1002–1006
  36. Milad MR, Quirk GJ. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 2002;420:70–74
  37. Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Bio. Psychiatry. 2007;62:446–454
  38. Mobbs D, Petrovic P, Marchant JL, Hassabis D, Weiskopf N, Seymour B, et al. When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans. Science (New York, NY. 2007;317:1079–1083
  39. Nagel JA, Huston JP. Enhanced inhibitory avoidance learning produced by post-trial injections of substance P into the basal forebrain. Behav Neural Biol. 1988;49:374–385
  40. Nyman MJ, Eskola O, Kajander J, Vahlberg T, Sanabria S, Burns D, et al. Gender and age affect NK1 receptors in the human brain – a positron emission tomography study with [18F]SPA-RQ. The international journal of neuropsychopharmacology/official scientific journal of the Collegium Internationale. Neuropsychopharmacologicum (CINP). 2007;10:219–229
  41. Ochsner KN, Ludlow DH, Knierim K, Hanelin J, Ramachandran T, Glover GC, et al. Neural correlates of individual differences in pain-related fear and anxiety. Pain. 2006;120:69–77
  42. Patlak CS, Blasberg RG. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab. 1985;5:584–590
  43. Picavet HS, Vlaeyen JW, Schouten JS. Pain catastrophizing and kinesiophobia: predictors of chronic low back pain. Am J Epidemiol. 2002;156:1028–1034
  44. Ploghaus A, Becerra L, Borras C, Borsook D. Neural circuitry underlying pain modulation: expectation, hypnosis, placebo. Trends Cogn Sci. 2003;7:197–200
  45. Rupniak NM, Carlson E, Boyce S, Webb JK, Hill RG. Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733, 060 in gerbils. Pain. 1996;67:189–195
  46. Rupniak NM, Webb JK, Williams AR, Carlson E, Boyce S, Hill RG. Antinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99, 994, in conscious gerbils. Br J Pharmacol. 1995;116:1937–1943
  47. Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheum. 1994;37:1593–1601
  48. Spielberger C, Gorsuch R, Lushene R. Manual for the state-trait anxiety inventory. Palo Alto, CA: Consulting Psychologists Press; 1970;
  49. Spitzer WO, Skovron ML, Salmi LR, Cassidy JD, Duranceau J, Suissa S, et al. Scientific monograph of the Quebec task force on whiplash-associated disorders: redefining “whiplash” and its management. Spine. 1995;20:1S–73S
  50. Stockmeier CA, Shi X, Konick L, Overholser JC, Jurjus G, Meltzer HY, et al. Neurokinin-1 receptors are decreased in major depressive disorder. Neuroreport. 2002;13:1223–1227
  51. Swinkels-Meewisse EJ, Swinkels RA, Verbeek AL, Vlaeyen JW, Oostendorp RA. Psychometric properties of the Tampa scale for kinesiophobia and the fear-avoidance beliefs questionnaire in acute low back pain. Man Ther. 2003;8:29–36
  52. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. Stuttgart: Georg Thieme Verlag; 1988;
  53. Vaeroy H, Helle R, Forre O, Kass E, Terenius L. Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis. Pain. 1988;32:21–26
  54. Vernon H, Mior S. The neck disability index: a study of reliability and validity. J Manipulative Physiol Ther. 1991;14:409–415
  55. Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci. 2005;6:533–544
  56. Zhao Z, Yang Y, Walker DL, Davis M. Effects of substance P in the amygdala, ventromedial hypothalamus, and periaqueductal gray on fear-potentiated startle. Neuropsychopharmacology. 2008;
  57. Wicksell RK, Ahlqvist J, Bring A, Melin L, Olsson GL. Can exposure and acceptance strategies improve functioning and life satisfaction in people with chronic pain and whiplash-associated disorders (WAD)? a randomized controlled trial. Cogn Behav Ther. 2008;37:1–14
  58. Woods MP, Asmundson GJ. Evaluating the efficacy of graded in vivo exposure for the treatment of fear in patients with chronic back pain: a randomized controlled clinical trial. Pain. 2008;136:271–280

PII: S0304-3959(10)00030-8

doi: 10.1016/j.pain.2010.01.008

PAIN
Volume 149, Issue 1 , Pages 64-70 , April 2010

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