PAIN
Volume 150, Issue 1 , Pages 29-40 , July 2010

Selectively targeting pain in the trigeminal system

  • Hyun Yeong Kim

      Affiliations

    • National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea
    • ,
  • Kihwan Kim

      Affiliations

    • National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea
    • ,
  • Hai Ying Li

      Affiliations

    • National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea
    • ,
  • Gehoon Chung

      Affiliations

    • National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea
    • ,
  • Chul-Kyu Park

      Affiliations

    • National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea
    • ,
  • Joong Soo Kim

      Affiliations

    • National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea
    • ,
  • Sung Jun Jung

      Affiliations

    • Department of Physiology School of Medicine, Hanyang University, Seoul 133-791, Republic of Korea
    • ,
  • Min Kyung Lee

      Affiliations

    • Department of Oral Physiology and Neurobiology School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea
    • ,
  • Dong Kuk Ahn

      Affiliations

    • Department of Oral Physiology and Neurobiology School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea
    • ,
  • Se Jin Hwang

      Affiliations

    • Department of Anatomy and Cell Biology College of Medicine, Hanyang University, Seoul 133-791, Republic of Korea
    • ,
  • Youngnam Kang

      Affiliations

    • Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan
    • ,
  • Alexander M. Binshtok

      Affiliations

    • Neural Plasticity Research Group, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA
    • ,
  • Bruce P. Bean

      Affiliations

    • Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    • ,
  • Clifford J. Woolf

      Affiliations

    • Neural Plasticity Research Group, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA
    • ,
  • Seog Bae Oh

      Affiliations

    • National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea
    • Corresponding Author InformationCorresponding author. Address: Department of Physiology, School of Dentistry, Seoul National University, 28-2 Yeongeon-Dong, Chongno-Ku, Seoul 110-749, Republic of Korea. Tel.: +82 2 740 8656; fax: +82 2 7625107.

Received 21 August 2009 ,Revised 5 December 2009 ,Accepted 9 February 2010.

References 

  1. Baranowski R, Lynn B, Pini A. The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species. Br J Pharmacol. 1986;89:267–276
  2. Bernardini N, Neuhuber W, Reeh PW, Sauer SK. Morphological evidence for functional capsaicin receptor expression and calcitonin gene-related peptide exocytosis in isolated peripheral nerve axons of the mouse. Neuroscience. 2004;126:585–590
  3. Binshtok AM, Bean BP, Woolf CJ. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature. 2007;449:607–610
  4. Binshtok AM, Gerner P, Oh SB, Puopolo M, Suzuki S, Roberson DP, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009;111:127–137
  5. Butterworth J, Oxford GS. Local anesthetics: a new hydrophilic pathway for the drug-receptor reaction. Anesthesiology. 2009;111:12–14
  6. Butterworth JFt, Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology. 1990;72:711–734
  7. Caterina MJ, Julius D. Sense and specificity: a molecular identity for nociceptors. Curr Opin Neurobiol. 1999;9:525–530
  8. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997;389:816–824
  9. Chen J, Kim D, Bianchi BR, Cavanaugh EJ, Faltynek CR, Kym PR, et al. Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain. 2009;5:3
  10. Chung JM, Lee KH, Hori Y, Willis WD. Effects of capsaicin applied to a peripheral nerve on the responses of primate spinothalamic tract cells. Brain Res. 1985;329:27–38
  11. Chung MK, Guler AD, Caterina MJ. TRPV1 shows dynamic ionic selectivity during agonist stimulation. Nat Neurosci. 2008;11:555–564
  12. Cummins TR, Sheets PL, Waxman SG. The roles of sodium channels in nociception: implications for mechanisms of pain. Pain. 2007;131:243–257
  13. Fang Z, Park CK, Li HY, Kim HY, Park SH, Jung SJ, et al. Molecular basis of Ca(v)2.3 calcium channels in rat nociceptive neurons. J Biol Chem. 2007;282:4757–4764
  14. Fried K, Bongenhielm U, Boissonade FM, Robinson PP. Nerve injury-induced pain in the trigeminal system. Neuroscientist. 2001;7:155–165
  15. Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD. Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther. 1998;285:413–421
  16. Kang Y, Saito M, Sato H, Toyoda H, Maeda Y, Hirai T, et al. Involvement of persistent Na+ current in spike initiation in primary sensory neurons of the rat mesencephalic trigeminal nucleus. J Neurophysiol. 2007;97:2385–2393
  17. Leffler A, Fischer MJ, Rehner D, Kienel S, Kistner K, Sauer SK, et al. The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest. 2008;118:763–776
  18. Leston JM. Functional anatomy of the trigeminal nerve. Neurochirurgie. 2009;55:99–112
  19. Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature. 1995;377:432–435
  20. McCleskey EW, Gold MS. Ion channels of nociception. Annu Rev Physiol. 1999;61:835–856
  21. McDavid S, Verdier D, Lund JP, Kolta A. Electrical properties of interneurons found within the trigeminal motor nucleus. Eur J Neurosci. 2008;28:1136–1145
  22. Meyers JR, MacDonald RB, Duggan A, Lenzi D, Standaert DG, Corwin JT, et al. Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J Neurosci. 2003;23:4054–4065
  23. Miyoshi T, Aida H, Kaneko Y. Comparative study on anesthetic potency of dental local anesthetics assessed by the jaw-opening reflex in rabbits. Anesth Prog. 2000;47:35–41
  24. Oh SB, Piao ZG, Shin SS, Ren D, Park K, Kim JS. GABAergic and serotonergic modulation of calcium currents in rat trigeminal motoneurons. Biochem Biophys Res Commun. 2003;309:58–65
  25. Ohkado S, Ichinohe T, Kaneko Y. Comparative study on anesthetic potency depending on concentrations of lidocaine and epinephrine: assessment of dental local anesthetics using the jaw-opening reflex. Anesth Prog. 2001;48:16–20
  26. Park CK, Kim K, Jung SJ, Kim MJ, Ahn DK, Hong SD, et al. Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system. Pain. 2009;144:84–94
  27. Park CK, Kim MS, Fang Z, Li HY, Jung SJ, Choi SY, et al. Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: implication for tooth pain. J Biol Chem. 2006;281:17304–17311
  28. Petsche U, Fleischer E, Lembeck F, Handwerker HO. The effect of capsaicin application to a peripheral nerve on impulse conduction in functionally identified afferent nerve fibres. Brain Res. 1983;265:233–240
  29. Qu Y, Rogers J, Tanada T, Scheuer T, Catterall WA. Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel. Proc Natl Acad Sci USA. 1995;92:11839–11843
  30. Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J, et al. Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg. 1991;72:275–281
  31. Sessle BJ. Acute and chronic craniofacial pain: brainstem mechanisms of nociceptive transmission and neuroplasticity, and their clinical correlates. Crit Rev Oral Biol Med. 2000;11:57–91
  32. Stanley FM. Handbook of local anesthesia 5e. New York, USA: Elsevier Inc.; 1994;
  33. Suzuki S, Gerner P, Colvin AC, Binshtok AM. C-fiber-selective peripheral nerve blockade. Open Pain J. 2009;2:24–29
  34. Taddese A, Nah SY, McCleskey EW. Selective opioid inhibition of small nociceptive neurons. Science. 1995;270:1366–1369
  35. Virginio C, MacKenzie A, Rassendren FA, North RA, Surprenant A. Pore dilation of neuronal P2X receptor channels. Nat Neurosci. 1999;2:315–321
  36. Wang H, Woolf CJ. Pain TRPs. Neuron. 2005;46:9–12
  37. Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT. Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000;28:959–965

PII: S0304-3959(10)00091-6

doi: 10.1016/j.pain.2010.02.016

PAIN
Volume 150, Issue 1 , Pages 29-40 , July 2010

Article Tools

* Image Usage & Resolution