Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and μ opioid receptor protein expression while enhancing perivascular microglial ED2

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Volume 150, Issue 3 , Pages 401-413, September 2010

Inhibition of microglial P2X₄ receptors attenuates morphine tolerance, Iba1, GFAP and μ opioid receptor protein expression while enhancing perivascular microglial ED2

Ryan J. Horvath
- Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
- Neuroscience Center at Dartmouth, Lebanon, NH 03756, USA
E. Alfonso Romero-Sandoval
- Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
- Neuroscience Center at Dartmouth, Lebanon, NH 03756, USA
- Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
Joyce A. De Leo
- Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
- Neuroscience Center at Dartmouth, Lebanon, NH 03756, USA
- Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
- Corresponding author. Address: Dartmouth Medical School, HB 7650, Hanover, NH 03755, USA. Tel.: + 1 603 650 1667; fax: +1 603 650 8525.

Received 12 October 2009; received in revised form 24 February 2010; accepted 26 February 2010. published online 23 June 2010.

PII: S0304-3959(10)00146-6

doi:10.1016/j.pain.2010.02.042

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PAIN September 2010 (Vol. 150, Issue 3, Pages 377-378)
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