PAIN
Volume 150, Issue 3 , Pages 377-378 , September 2010

Targeting microglial purinergic signaling to improve morphine analgesia

  • Ru-Rong Ji

      Affiliations

    • Corresponding Author InformationAddress: Department of Anesthesiology, Brigham and Women’s Hospital, 75 Francis Street, Medical Research Building, Room 604, Boston, MA 02115, USA. Tel.: +1 617 732 8852; fax: +1 617 730 2801.

Received 22 March 2010 ,Accepted 11 June 2010.

References 

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  2. Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005;438:1017–1021
  3. Cui Y, Chen Y, Zhi JL, Guo RX, Feng JQ, Chen PX. Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance. Brain Res. 2006;1069:235–243
  4. Horvath RJ, Romero-Sandoval EA, Deleo JA. Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and μ opioid receptor protein expression while enhancing perivascular microglial ED2. Pain. 2010;150:401–413
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  10. Trang T, Beggs S, Wan X, Salter MW. P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J Neurosci. 2009;29:3518–3528
  11. Tsuda M, Kuboyama K, Inoue T, Nagata K, Tozaki-Saitoh H, Inoue K. Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays. Mol Pain. 2009;5:28
  12. Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003;424:778–783
  13. Watkins LR, Hutchinson MR, Johnston IN, Maier SF. Glia: novel counterregulators of opioid analgesia. Trends Neurosci. 2005;28:661–669

PII: S0304-3959(10)00355-6

doi: 10.1016/j.pain.2010.06.010

PAIN
Volume 150, Issue 3 , Pages 377-378 , September 2010

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