Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

Willemen, Hanneke L.D.M.; Eijkelkamp, Niels; Wang, Huijing; Dantzer, Robert; Dorn, Gerald W.; Kelley, Keith W.; Heijnen, Cobi J.; Kavelaars, Annemieke

doi:10.1016/j.pain.2010.06.015

« Previous Next »PAIN
Volume 150, Issue 3 , Pages 550-560, September 2010

Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

Hanneke L.D.M. Willemen
- Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD), University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
- These authors contributed equally to this work.
Niels Eijkelkamp
- Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD), University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
- Integrative Immunology and Behavior Program, College of ACES and College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
- These authors contributed equally to this work.
Huijing Wang
- Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD), University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
Robert Dantzer
- Integrative Immunology and Behavior Program, College of ACES and College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Gerald W. Dorn II
- Center for Pharmacogenomics, Washington University, St. Louis, MI 63110, USA
Keith W. Kelley
- Integrative Immunology and Behavior Program, College of ACES and College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Cobi J. Heijnen
- Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD), University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
- Integrative Immunology and Behavior Program, College of ACES and College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Annemieke Kavelaars
- Laboratory of Neuroimmunology and Developmental Origins of Disease (NIDOD), University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
- Integrative Immunology and Behavior Program, College of ACES and College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
- Corresponding author at: Laboratory for Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Lundlaan 6, Office KC 03.068.0, 3584 EA Utrecht, The Netherlands. Tel.: +31 88 755 4359; fax: +31 88 755 5311.