PAIN
Volume 82, Supplement 1 , Pages S127-S132, August 1999

Neurotrophin action on sensory neurons in adults: an extension of the neurotrophic hypothesis

Department of Neurobiology and Behaviour, State University of New York, Stony Brook, NY 11794-5230, USA

Abstract 

This brief review explores the action of neurotrophins on sensory neurons in adults. Neutralization of neurotrophins in adults does not cause sensory neurons to die as it does in prenatal animals. Thus they are not required as survival factors in adults. However, neurotrophins continue to play important roles in the postnatal development of sensory neurons. They also exert strong effects on the anatomy and physiology of these fibers after axotomy in adults. Here we review of the effects of NT-3 on spindle afferent fibers and NGF on nociceptive afferents and consider possible extension of the neurotrophic hypothesis to adults.

Keywords:  Neurotrophic hypothesis, Neurotrophins, Sensory neurons, NGF, NT-3

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PII: S0304-3959(99)00146-3

PAIN
Volume 82, Supplement 1 , Pages S127-S132, August 1999

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