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Editorial list
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How does topical lidocaine relieve pain
07 November 2011
The report by Krumova et al. in this issue raises important questions about the neural signaling involved in neuropathic pain, and highlights the presence of substantial gaps in our knowledge about h...
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James N. Campbell
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255-256
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Modelling pain in post-traumatic osteoarthritis of the knee
24 October 2011
Osteoarthritis (OA) pain represents a major unmet medical need. OA is the most common joint disorder, affecting primarily the knees, hips, hands, and spine . A recent American College of Rheumatology ...
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Anne-Marie Malfait
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257-258
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The role of co-morbidity in accumulating risk of chronic pain
21 November 2011
In this issue of Pain Dominick et al. investigate the association between physical and mental co-morbidity and the prevalence of chronic pain in a population-based sample of adults. Numerous studies ...
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Danielle van der Windt
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259-260
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What does an increased prevalence of behavioral and psychological symptoms of dementia in individuals with pain mean?
28 November 2011
There is a growing international interest in the topic of pain in persons with dementia. To date, research efforts have mainly focused on the development of valid and reliable pain assessment tools, p...
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Stephen J. Gibson
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261-262
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One failed clinical trial (of 5HT3 antagonists) does not invalidate the concept
12 December 2011
In this issue of PAIN, Neziri et al. present data from a well-designed and very significant study of chronic low back pain patients. Pain and signs of central hypersensitivity in chronic low back pai...
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Matti Förster,
Ralf Baron
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263-264
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| Topical reviews |
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Estimate at your peril: Imputation methods for patient withdrawal can bias efficacy outcomes in chronic pain trials using responder analyses
07 November 2011
Patient withdrawal from randomised trials is common in chronic pain trials, and more common for the experimental drug than for placebo . Different analysis strategies can be used to deal with missing ...
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R. Andrew Moore,
Sebastian Straube,
Christopher Eccleston,
Sheena Derry,
Dominic Aldington,
Philip Wiffen,
Rae F. Bell,
Katri Hamunen,
Ceri Phillips,
Henry McQuay
et al.
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265-268
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Are we neglecting spinal reorganization following nerve damage?
21 November 2011
Neuroplastic changes can be demonstrated in the brain following damage to the central and peripheral nervous system using imaging techniques such as positron emission tomography, functional magnetic r...
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Nanna Brix Finnerup,
Lone Nikolajsen,
Troels Staehelin Jensen
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269-272
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| Research papers |
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Lidocaine patch (5%) produces a selective, but incomplete block of Aδ and C fibers
13 October 2011
Summary: Topical lidocaine (5%) induced a selective, but only partial blockade of Ad- and C-fibers of variable magnitude in healthy subjects, with significantly increased thermal detection and mechani...
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Elena K. Krumova,
Martina Zeller,
Andrea Westermann,
Christoph Maier
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273-280
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Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL/6 mice
17 October 2011
Summary: Partial medial meniscectomy produces progressive degenerative joint disease and accompanying evoked pain behaviours in C57Bl/6 mice, providing a model for the study of osteoarthritic pain beh...
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Chancie Bayer Knights,
Clive Gentry,
Stuart Bevan
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281-292
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Unpacking the burden: Understanding the relationships between chronic pain and comorbidity in the general population
09 November 2011
Summary: Accumulated comorbid load is independently associated with chronic pain. Comorbid physical conditions increase risk additively, while anxiety/depression interacts with 2 specific conditions, ...
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Clare H. Dominick,
Fiona M. Blyth,
Michael K. Nicholas
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293-304
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Association of pain with behavioral and psychiatric symptoms among nursing home residents with cognitive impairment: Results from the SHELTER study
17 November 2011
Summary: Evidence from a large sample of frail elderly people in nursing homes reveals an association between pain and behavioral and psychiatric symptoms.Abstract: The etiology of behavioral and psyc...
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Matteo Tosato,
Albert Lukas,
Henriette G. van der Roest,
Paola Danese,
Manuela Antocicco,
Harriet Finne-Soveri,
Thorsten Nikolaus,
Francesco Landi,
Roberto Bernabei,
Graziano Onder
et al.
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305-310
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Effect of intravenous tropisetron on modulation of pain and central hypersensitivity in chronic low back pain patients
21 November 2011
Summary: Single-dose intravenous administration of tropisetron in patients with chronic low back pain failed to affect the intensity of pain and parameters of central hypersensitivity.Abstract: The ac...
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Alban Y. Neziri,
Martina Dickenmann,
Pasquale Scaramozzino,
Ole K. Andersen,
Lars Arendt-Nielsen,
Anthony H. Dickenson,
Michele Curatolo
et al.
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311-318
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A randomized controlled evaluation of an online chronic pain self management program
02 December 2011
Summary: Use of the Chronic Pain Management Program was associated with significant decreases in pain-related, functional, and mental health outcomes and an increase in pain knowledge.Abstract: Intern...
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Linda S. Ruehlman,
Paul Karoly,
Craig Enders
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319-330
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Psychophysical and cerebral responses to heat stimulation in patients with central pain, painless central sensory loss, and in healthy persons
30 November 2011
Summary: Patients with central pain have a more hyperresponsive intralaminar thalamus and sensory–motor cortex than healthy individuals or patients with central lesions and painless sensory loss.Abstr...
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Kenneth L. Casey,
Michael Geisser,
Jürgen Lorenz,
Thomas J. Morrow,
Pamela Paulson,
Satoshi Minoshima
et al.
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331-341
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Patient perspective on herpes zoster and its complications: An observational prospective study in patients aged over 50 years in general practice
05 December 2011
Summary: Despite early diagnosis and treatment with antiviral agents, many herpes zoster patients report persistent pain and marked long-term reduction in health-related quality of life.Abstract: Unde...
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Didier Bouhassira,
Olivier Chassany,
Jacques Gaillat,
Thomas Hanslik,
Odile Launay,
Claude Mann,
Christian Rabaud,
Olivier Rogeaux,
Christophe Strady
et al.
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342-349
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Are both the sensory and the affective dimensions of pain encoded in the face?
23 November 2011
Summary: The facial expression of pain is a multidimensional response system that differentially encodes affective and sensory pain qualities.Abstract: The facial expression of pain plays a crucial ro...
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Miriam Kunz,
Stefan Lautenbacher,
Nadine LeBlanc,
Pierre Rainville
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350-358
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Prevalence and aetiology of neuropathic pain in cancer patients: A systematic review
24 November 2011
Summary: One in 5 cancer pains are neuropathic, and 2 in 5 patients have neuropathic pain. Standard approaches to assess cancer neuropathic pain are needed.Abstract: Pain in cancer patients remains co...
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Michael I. Bennett,
Clare Rayment,
Marianne Hjermstad,
Nina Aass,
Augusto Caraceni,
Stein Kaasa
et al.
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359-365
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The complement component C5a receptor mediates pain and inflammation in a postsurgical pain model
02 December 2011
Summary: Complement C5a receptor deletion prevents heat and mechanical nociceptive responses and generation of inflammatory and nociceptive mediators in superficial and deep tissues after incision.Abs...
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De-Yong Liang,
XiangQi Li,
Xiaoyu Shi,
Yuan Sun,
Peyman Sahbaie,
Wen-Wu Li,
J. David Clark
et al.
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366-372
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Effects of spatially targeted transcutaneous electrical nerve stimulation using an electrode array that measures skin resistance on pain and mobility in patients with osteoarthritis in the knee: A randomized controlled trial
28 November 2011
Summary: An electrode array enabled transcutaneous electrical nerve stimulation (TENS) treatment at sites of lowest skin resistance which reduced movement-related osteoarthritic knee pain more than ad...
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Alexander F. Kolen,
Ron N.J. de Nijs,
Femke M. Wagemakers,
Anna J.L. Meier,
Mark I. Johnson
et al.
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373-381
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Neural mechanisms mediating the effects of expectation in visceral placebo analgesia: An fMRI study in healthy placebo responders and nonresponders
05 December 2011
Summary: In this placebo analgesia study, the expectation of pain relief reduced perceived painfulness of visceral stimuli, which was associated with activity changes in thalamus, and prefrontal and s...
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Sigrid Elsenbruch,
Vassilios Kotsis,
Sven Benson,
Christina Rosenberger,
Daniel Reidick,
Manfred Schedlowski,
Ulrike Bingel,
Nina Theysohn,
Michael Forsting,
Elke R. Gizewski
et al.
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382-390
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Double spikes to single electrical stimulation correlates to spontaneous activity of nociceptors in painful neuropathy patients
09 December 2011
Summary: Spontaneously active C nociceptors in painful neuropathy patients reveal multiple firing to single electrical stimuli, suggesting that axonal hyperexcitability contributes to neuropathic pain...
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Roland Schmidt,
Inge Petter Kleggetveit,
Barbara Namer,
Tormod Helås,
Otilia Obreja,
Martin Schmelz,
Ellen Jørum
et al.
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391-398
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Unmyelinated and myelinated skin nerve damage in Guillain–Barré syndrome: Correlation with pain and recovery
12 December 2011
Summary: Unmyelinated and myelinated skin nerves are diffusely affected in Guillain–Barré syndrome and its variants. Intraepidermal nerve fiber density declines early, remains low over time, correlate...
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Liselotte Ruts,
Pieter A. van Doorn,
Raffaella Lombardi,
Elize D. Haasdijk,
Paola Penza,
Joke H.M. Tulen,
Roelie J. Hempel,
Anton H. van den Meiracker,
Giuseppe Lauria
et al.
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399-409
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Purinergic receptor P2Y1 regulates polymodal C-fiber thermal thresholds and sensory neuron phenotypic switching during peripheral inflammation
02 December 2011
Summary: The purinergic receptor P2Y1 modulates the thermal sensitivity of polymodal fibers and the functional phenotype of TRPV1-containing cutaneous fibers following inflammation.Abstract: We have r...
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Michael P. Jankowski,
Kristofer K. Rau,
Deepak J. Soneji,
Katrina M. Ekmann,
Collene E. Anderson,
Derek C. Molliver,
H. Richard Koerber
et al.
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410-419
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Experimental characterization of the effects of acute stresslike doses of hydrocortisone in human neurogenic hyperalgesia models
19 December 2011
Summary: A moderate dose of hydrocortisone reduced capsaicin-induced secondary hyperalgesia, but not pain to pinprick suggesting an antihyperalgesic action of glucocorticoids consistent with protectio...
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Gilles P.N. Michaux,
Walter Magerl,
Fernand Anton,
Rolf-Detlef Treede
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420-428
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Impact of pain on the course of depressive and anxiety disorders
12 December 2011
Summary: The course of depressive and anxiety disorders in a large, longitudinal cohort study was poorer when pain was present, which was partly mediated by baseline psychiatric characteristics.Abstra...
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Marloes M.J.G. Gerrits,
Nicole Vogelzangs,
Patricia van Oppen,
Harm W.J. van Marwijk,
Henriette van der Horst,
Brenda W.J.H. Penninx
et al.
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429-436
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Too sick for school? Parent influences on school functioning among children with chronic pain
12 December 2011
Summary: Parental protective responses to pain mediated the association between parent pain catastrophizing and child school functioning as assessed by school attendance and subjective report. Promoti...
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Deirdre E. Logan,
Laura E. Simons,
Elizabeth A. Carpino
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437-443
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Sex similarities and differences in pain-related periaqueductal gray connectivity
09 December 2011
Summary: Pain induces changes in the functional connectivity between the periaqueductal gray and the cingulate, and, in men more than women, connectivity changes to the amygdala.Abstract: This study i...
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Clas Linnman,
Jan-Carl Beucke,
Karin B. Jensen,
Randy L. Gollub,
Jian Kong
et al.
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444-454
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Practice, practitioner, or placebo? A multifactorial, mixed-methods randomized controlled trial of acupuncture
14 December 2011
Summary: This multifactorial mixed-methods randomized controlled trial quantified the specific and nonspecific factors of acupuncture, and found that the practitioner, not the treatment, has the stron...
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Peter White,
Felicity L. Bishop,
Phil Prescott,
Clare Scott,
Paul Little,
George Lewith
et al.
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455-462
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Differential effects of experimental central sensitization on the time-course and magnitude of offset analgesia
08 December 2011
Summary: Despite observations of thermal hyperalgesia, mechanical allodynia, and temporal alterations of offset analgesia, the magnitude of offset analgesia remains unaltered following capsaicin-heat ...
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Katherine T. Martucci,
Marc D. Yelle,
Robert C. Coghill
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463-472
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Menthol pain relief through cumulative inactivation of voltage-gated sodium channels
15 December 2011
Summary: Menthol acts a state-selective blocker of voltage-gated Na+ channels and causes antinociception in mice, providing a molecular basis for its analgesic action.Abstract: Menthol is a natural co...
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Christelle Gaudioso,
Jizhe Hao,
Marie-France Martin-Eauclaire,
Mélanie Gabriac,
Patrick Delmas
et al.
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473-484
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Immune conditions associated with CD4+ T effector-induced opioid release and analgesia
22 December 2011
Summary: Endogenous analgesia is a delta opioid-mediated CD4+ T effector function, dependent on recognition of the antigen within the inflammatory site.Abstract: Effector CD4+ T lymphocytes generated ...
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Jérôme Boué,
Catherine Blanpied,
Marilena Djata-Cabral,
Lucette Pelletier,
Nathalie Vergnolle,
Gilles Dietrich
et al.
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485-493
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Group cognitive behavioural interventions for low back pain in primary care: Extended follow-up of the Back Skills Training Trial (ISRCTN54717854)
09 January 2012
Summary: Long-term follow-up of a randomised controlled trial of a cognitive behavioural intervention for low back pain indicates that effects on disability and pain are maintained to at least 34 mont...
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Sarah E. Lamb,
Dipesh Mistry,
Ranjit Lall,
Zara Hansen,
David Evans,
Emma J. Withers,
Martin R. Underwood,
On behalf of the Back Skills Training Trial Group.
et al.
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494-501
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| Letters to the Editor |
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Noppers et al., Drug-induced liver injury following a reported course of ketamine treatment for chronic pain in CRPS type I patients. A report on 3 cases. Pain 2011;152:2173–8
09 December 2011
We have read with great interest the article by Noppers et al. , as well as the accompanying editorial , on liver injury following repeated intravenous ketamine treatment of complex regional pain synd...
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Dagmar Westerling,
Peter Lindblom
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502
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S(+)-Ketamine analgesic drug dose
12 December 2011
We thank Drs. Westerling and Lindblom for their careful reading of our paper on drug-induced liver injury following a repeated course of S(+)-ketamine treatment for chronic pain in patients with compl...
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Albert Dahan,
Ingeborg Noppers,
Marieke Niesters,
Leon Aarts,
Elise Sarton,
Asbjørn M. Drewes
et al.
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502-503
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